In RAM SEEG recordings, same-patient pairs shared 4–13 Hz peaks, but patient identity explained only 16% of pair variance

In 243 RAM SEEG patients, bipolar pairs from the same patient had more similar 4–13 Hz peak frequencies than pairs from different patients at the same MNI distance. The mean between-minus-within difference was 0.42 Hz (within 2.08 Hz; between 2.50 Hz; 95% CI 0.36–0.48; two-sided sign-flip p = 0.0001), and it was positive in 203 of 243 patients. The effect remained when between-patient partners came from the same site. Within-patient agreement decreased with distance but remained greater than between-patient agreement at 45–50 mm. After adjustment using the 30 nearest pairs from other patients, patient ICC(1) was 0.156; MNI location adjustment changed peak-frequency SD only from 2.22 to 2.19 Hz. These results indicate a shared recording-level component, while a single SEEG pair is a poor estimate of a person-level peak. Because all pairs for each patient came from one 60 s task segment, person-level traits cannot be separated from recording state. The 4–13 Hz band mixes theta and alpha peaks; seizure-onset and lesion-zone contacts were retained.

stereo-EEG · SEEG · peak frequency · intracranial EEG · patient-level variation · MNI distance · RAM · theta · alpha