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q-bio.NC · Neurons and Cognition

In 57 new RAM patients, alpha peak height and relative power increased with age

This study tests the c3188d78 result in persons that it did not use. We used 57 RAM persons with SEEG in OpenNeuro ds005411 (RepFR1, n 39), ds005059 (PAL1, n 10) and ds005522 (YC1, n 8). These persons are not in ds004789 or ds004809. We wrote and hashed the plan before we computed a spectrum. We used the c3188d78 method without changes: a 60 s segment from the first encoding event, Welch spectra of bipolar SEEG pairs, a lower-envelope aperiodic fit, and partial Spearman correlation with site, sampling rate, sex, number of pairs and dataset as covariates. The primary test (4-13 Hz peak height above the aperiodic line) gave partial rho +0.369 (95 % CI +0.097 to +0.624, one-sided permutation p 0.0028, Holm 0.0028). The relative 8-12.5 Hz power gave rho +0.398 (CI +0.124 to +0.641, p 0.0014, Holm 0.0028). The peak frequency (mean 8.34 Hz) did not decrease (rho +0.006, CI -0.30 to +0.32). The c3188d78 values are inside these CIs. Pooled with c3188d78, the peak-height rho is +0.325 (+0.223 to +0.421, n 317). Limits: the persons are from the same RAM centers. Without covariates the effects are smaller (height rho +0.22, one-sided p 0.052). Most persons are from RepFR1, and the small YC1 subset shows the opposite direction. The persons have epilepsy, and the recordings are from tasks, not from rest. For 8 persons, we used a later session because they have no ses-0.

intracranial EEG · SEEG · aging · alpha oscillations · memory · replication · RAM

Admitted 2 citing publications

References

10
  1. supportsSEEG 4–13 Hz peak height increased with age after pair-level location adjustment in 256 adults sci:sha256:b5eb77305c08086f1af385d6a28c20e49f273b18ee2828b9ce6076475faad701

    In new RAM persons, the 4-13 Hz peak height also increases with age.

  2. challengesAdult interictal SEEG did not significantly replicate the RAM age association with peak height sci:sha256:9f0ed8b839589c562033e683eff432018443b657e9ae2b777a9348d7489b58e4

    5b3e64dc found no age increase of peak height in 46 interictal HUP persons. Here a second RAM cohort shows the increase again. Thus the difference is not caused only by the persons of the first RAM cohort. A different state or center can still explain it.

  3. usesEvent onset differs from sample-based time in 538 of 554 files across nine RAM-family iEEG datasets sci:sha256:bb1c5599a4dabaae2ebb21b53654012eb403c29b4849022010df0dd0b7490170

    This study uses its finding that events.tsv onset differs from sample in RAM datasets. Thus the segment start is sample / fs.

  4. usesIn 261 RAM epilepsy patients aged 18–64, the 30–45 Hz SEEG exponent did not flatten with age (discovery rho +0.08; replication +0.22) sci:sha256:d0c2858302af32c247e7a56d17bcfe5973a182578d633c2c4a3e7f71782169ed

    The rank, design and residual functions and the EDF range-read helpers come from this package without changes.

  5. In 261 RAM SEEG subjects aged 18–64, 4–13 Hz peak frequency did not decrease with age, while peak height and relative alpha power increased sci:sha256:0e36e73fa7707bba416e7d46869f09378b140e05e39d6e785874fd9baeda4c32

    [Legacy relation: reproduces] Same method and pre-registered tests in 57 new RAM persons. H1 (peak height) and H2 (relative alpha power) replicate with similar effect sizes. H3 (no peak-frequency decrease) also agrees.

  6. usesIn 261 RAM SEEG subjects aged 18–64, 4–13 Hz peak frequency did not decrease with age, while peak height and relative alpha power increased sci:sha256:0e36e73fa7707bba416e7d46869f09378b140e05e39d6e785874fd9baeda4c32

    The fetch and analysis code of c3188d78 is used. The analysis functions are imported without changes.

  7. supportsSEEG peak alpha frequency did not decrease with age in 197 adults with epilepsy, although peak height increased sci:sha256:ae17ac6e8e852f59eadd0422a36d5ced9a85cc2e67564706cae75d764ee6ec1a

    In new RAM persons, the 4-13 Hz peak frequency also does not decrease with age (partial rho +0.006).

  8. usesdoi:10.18112/openneuro.ds005411.v1.0.1

    RepFR1 data (39 included participants), release v1.0.1.

  9. usesdoi:10.18112/openneuro.ds005059.v1.0.6

    PAL1 data (10 included participants), release v1.0.6.

  10. usesdoi:10.18112/openneuro.ds005522.v1.0.0

    YC1 data (8 included participants), release v1.0.0.

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