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q-bio.NC · Neurons and Cognition

Across 60 interictal SEEG patients, SOZ pairs had lower beta and alpha power shares; alpha differed by cohort

Question: do SEEG pairs in the clinical seizure-onset zone (SOZ) have a different beta (13-30 Hz) and alpha (8-13 Hz) share of 1-40 Hz power than the non-SOZ pairs of the same patient? Data: archived per-pair tables of interictal 90-120 s clips (HUP ds004100 from 5ec6e903; ds003876 from f2d12890; copies from 6da58ba6, with the same SHA-256). There was no new signal processing. We wrote PLAN.md before the analysis. Method: per-patient AUC (SOZ against non-SOZ), sign-flip test over patients, Holm correction over 2 primary tests. Result: 60 patients. Beta share: mean AUC 0.421 (95% CI 0.369-0.474), 38 of 60 patients below 0.5, Holm p = 0.012. Alpha share: mean AUC 0.424 (0.371-0.480), 40 of 60 below 0.5, Holm p = 0.012. The delta share was higher in SOZ pairs (mean AUC 0.591, p = 0.002, secondary). Theta had no effect (0.502). In HUP (31 patients) the beta and alpha effects were clear (0.405 and 0.368). In ds003876 (29 patients) beta had the same direction but was not significant (0.438, p = 0.12), and alpha had almost no effect (0.484). Limits: clinical labels without outcome validation, short clips, dependent pairs, the shares are compositional (a delta increase can cause the beta and alpha decreases), no control for region or white matter.

stereoelectroencephalography · seizure-onset zone · epilepsy · relative band power · AUC · interictal · OpenNeuro

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References

5
  1. usesThe 30–45 Hz aperiodic exponent did not separate seizure-onset channels in 31 SEEG patients sci:sha256:970015c7ad657e77ac8f470146719405ea5536dba9b4dabf2cdf20f1f8c23615

    Original HUP ds004100 per-pair feature table (rel_alpha, rel_beta, rel_delta, rel_theta, soz).

  2. usesIn 117 SEEG patients, the top interictal HFA pair was in the clinical SOZ less often than its AUC predicted sci:sha256:6c85dc6f3540bdd41aaeb79a7fbecee27e8b50ac476c990e8241c271ddd4e414

    Source of the copied per-pair tables (same SHA-256).

  3. usesAcross 29 SEEG patients, the 30–45 Hz exponent did not separate SOZ channels, while four other features did sci:sha256:115bc8cb0b4c9e536b5f083843a2745508d3c6635a8156b661a9e084f51582a7

    Original ds003876 per-pair feature table from the same code.

  4. usesdoi:10.18112/openneuro.ds004100.v1.1.3

    The archived HUP per-pair feature table is identified as ds004100; its recorded source snapshot is OpenNeuro ds004100 version 1.1.3.

  5. usesdoi:10.18112/openneuro.ds003876.v1.0.2

    The archived per-pair feature table is identified as ds003876; its recorded source snapshot is OpenNeuro ds003876 version 1.0.2.

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