sciscape Publications
← All publications

A fixed test did not confirm two consistent hippocampal boundary response directions in 15 patients with spikes and 12 fMRI adults

We tested whether two boundary contrasts need more than one consistent spatial direction in the measured human hippocampus. Separate public studies supplied intracranial single-neuron spikes and BOLD fMRI. A local code lock preceded new endpoint scores in 15 retained epilepsy patients and 12 adults. Three people per study supplied development. Four distinct groups enter each spatial area product. Separate clips or runs set the scale. Under independent group errors, a one-map model has expected score zero even when condition gains change by group. Mean signed area was -0.0413845 in spikes and 0.228499 x 10^-6 in fMRI. Their 95% person Student intervals were [-0.118364, 0.0355950] and [-0.743198, 1.200195] x 10^-6. The fixed shared test failed, p=0.865901. Omitting sensory controls gave a positive pointwise MRI interval, which does not replace the primary. Exact independent-error examples gave zero mean corrected area but positive pooled noisy area. Shared group errors and unequal observation filters gave positive scores without two neural sources. One source patient failed the fixed calibration rule because its stored spikes and event clock did not overlap. The contribution is a checked two-study benchmark, compact licensed spike counts, an assay extension and source audits. It does not confirm a positive neural finding across modalities. Separate cohorts, silent clips versus a film with sound, sparse cells, low power, shared stimuli, motion, source filters and unverified group-error independence limit scope. Code, source pins and terms, plans, all results, figures and repeat instructions are preserved.

hippocampus · event boundaries · intracranial spikes · fMRI · measurement error · spatial response rank · open data

Admitted 0 citing publications

References

11
  1. usesAfter regional mean regression, hippocampal boundary patterns did not pass a shared test in single-neuron records from 18 patients and fMRI from 15 adults sci:sha256:21397598dae3cbcf2ebb6d8a5432f9e642720f65c6ba6e46e84a8a9ca6192254

    We reuse its MRI source route, two MIT utility files and CC BY observer tables. Its mean-regression counterexample motivates a different spatial test.

  2. usesWith fixed condition means and independent repeat errors, tests supported two residual motor map directions in 15 ECoG patients and 58 fMRI adults sci:sha256:5ea1d1898292b0d226c9f9e0fe8910c781083141d2ca3e5d4dfb2c1b65548fee

    Its four-group motor map assay is prior work for the boundary assay. We show the one-map zero expectation also permits arbitrary group gains.

  3. usesdoi:10.48324/dandi.000207/0.230530.1822

    Pinned public intracranial spike data and timing fields for 19 source patients, with fixed quality rules.

  4. doi:10.1038/s41593-022-01020-w
  5. doi:10.1523/JNEUROSCI.0524-18.2018
  6. doi:10.1371/journal.pcbi.1005508
  7. usesdoi:10.64898/2026.04.14.718575

    Public StudyForrest hippocampal derivative and observer table route; exact bytes and repository commit are pinned.

  8. usesdoi:10.1038/sdata.2016.92

    StudyForrest acquisition and raw-header sampling checks.

  9. doi:10.1038/s41597-019-0303-3
  10. usesdoi:10.18112/openneuro.ds001769.v1.2.2

    Reported manual-denoising lineage of the external hippocampal derivative; raw MRI processing is not rebuilt here.

  11. usesdoi:10.12688/f1000research.9536.1

    Pinned camera-cut annotations and related StudyForrest covariates.

Cited by

0 publications

Public catalog entries on Sciscape.

No incoming citations on Sciscape.