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Late hippocampal theta testing did not detect accuracy differences in 14 SEEG patients under patient independence and null sign symmetry

We tested hippocampal theta power before correct and incorrect verbal memory responses. The primary sample had 1,700 trials from 14 patients with epilepsy. Each trial followed a correct response. The model controlled session, memory load, trial position, probe type, and fixation power. The equal patient mean was +0.211 dB for correct minus incorrect responses. The 95 percent patient bootstrap interval was -0.132 to +0.547 dB. The exact two-sided sign-flip p value was 0.2595. This test assumes independent patient effects and null sign symmetry. The test did not detect a difference at alpha 0.05. The result does not prove equal power. Five planned secondary tests did not pass Holm correction. The package contains source features, metadata, trial tables, code, results, and raw retrieval instructions. A new raw session check matched all 16 feature arrays. Independent numerical checks passed.

hippocampus · theta power · verbal working memory · SEEG · response accuracy · epilepsy

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References

5
  1. supersedesLate hippocampal theta testing did not detect accuracy differences in 14 SEEG patients under patient independence and null sign symmetry sci:sha256:ebe45e185cd248ef4049f29e60fc76bcd33d1b0aa77f4c4ff6efa2ec2ea993b4

    This version corrects the package audit for the metadata folder that AutoSci adds during retrieval. The source data, analysis code, and scientific results have identical sizes and hashes. The new audit was tested on a package retrieved from AutoSci.

  2. usesThe late maintenance hippocampal theta load estimate had a bootstrap interval that included zero after correct responses in 14 patients sci:sha256:add166482e6e9f32d495f27bed3a0e731563a2cd7daa8fcfd86b9f170fb123e5

    This publication supplied the ds004752 version 1.0.1 contact features, source metadata, raw hashes, and extraction code. We checked its archive and rebuilt one raw session. We used these inputs for a new response correctness test within session and memory load.

  3. usesdoi:10.18112/openneuro.ds004752.v1.0.1

    The analysis uses contact features, metadata, and fixed raw source objects from OpenNeuro ds004752 version 1.0.1.

  4. doi:10.7554/eLife.78677
  5. supportsdoi:10.1038/s41597-020-0364-3

    This paper documents the task rule that reduces load after an incorrect response, which motivates the primary restriction to trials after correct responses.

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