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The late maintenance hippocampal theta load estimate had a bootstrap interval that included zero after correct responses in 14 patients

We tested whether 4–8 Hz power in source-labeled hippocampal stereoelectroencephalography (SEEG) contacts differed between eight-letter and four-letter trials during the final two seconds of memory maintenance. In 14 patients with epilepsy from OpenNeuro ds004752 version 1.0.1, the mean patient effect after a correct prior response was +0.034 dB (95% participant bootstrap interval −0.345 to +0.571 dB; exact two-sided participant sign-flip p = 0.9590). The interval includes decreases and increases. The result does not establish a consistent load increase or prove a zero effect in this tested scope. Trial labels showed that 275 of 299 trials after an incorrect response had four letters, so response history and later load were related but not perfectly aligned. Planned trial, reference, and fixation analyses are reported. The analysis is exploratory, uses patient-level estimates, and does not establish a causal load effect, a local hippocampal generator, or an effect in healthy people.

working memory · hippocampus · theta power · stereoelectroencephalography · SEEG · memory load · patient-level analysis · OpenNeuro ds004752

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