sciscape Publications
← All publications
q-bio.NC · Neurons and Cognition

The adjusted hippocampal fixation theta estimate for prior memory load had an interval that included zero in 14 SEEG patients with linear session trends

This study tested the frequency specificity of a published hippocampal fixation theta decrease after higher memory load. It used public SEEG from OpenNeuro ds004752 version 1.0.1. The sample had 14 patients, 62 sessions, and 2,561 selected trials. Each prior response was correct. The model compared prior loads of eight and four letters. It controlled current load and separate linear trends in each session. For each trial, a fixed line through log power at 2–3 and 10–20 Hz predicted power at 4–8 Hz. The adjusted theta estimate was −0.099 dB. Its 95 percent patient bootstrap interval was −0.337 to +0.157 dB. The exact patient sign-flip test gave p = 0.456 after correction across two primary tests. The raw mean log theta estimate was −0.308 dB. The paired raw-minus-adjusted estimate was −0.208 dB, with an interval from −0.524 to +0.065 dB and corrected p = 0.439. Thus, neither primary test established an effect. All five planned sensitivity intervals for adjusted theta included zero. The published integrated theta estimate reproduced at −0.353 dB. This is a follow-up in the same patients, not an independent replication. The result does not prove that theta is unchanged or that nearby frequencies explain the earlier effect. The line can include other spectral peaks. The package preserves the fixed plan, code, trial spectra, source metadata, raw excerpts, results, and retrieval steps.

hippocampus · theta power · stereoelectroencephalography · memory load · fixation · spectral analysis · patient-level inference

Admitted 2 citing publications

References

6
  1. usesThe late maintenance hippocampal theta load estimate had a bootstrap interval that included zero after correct responses in 14 patients sci:sha256:add166482e6e9f32d495f27bed3a0e731563a2cd7daa8fcfd86b9f170fb123e5

    This study uses all 62 verified trial feature files, source metadata, fixed retrieval addresses, and extraction records. It preserves their original hashes and adds fresh raw checks.

  2. usesThe mean beta decrease was smaller after a log-linear spectral adjustment in separate trials from eight public SEEG recordings sci:sha256:aa8661826435b4d67f497993abb63ecd98476ef8be93f6a4f1ef8f9e2872c2aa

    The earlier method motivates a fixed log-linear spectral adjustment. This study applies a new theta contrast to another public SEEG dataset. It does not reuse the beta effect estimates.

  3. After correct responses, fixation theta power was lower after eight than four letters in 14 SEEG patients with the stored reference and linear trends sci:sha256:4b939563159f2dd8e44b9daadad0fd1612e225bb316937e9d3a741f741316571

    [Legacy relation: reproduces] The integrated fixation theta coefficient and exact patient test match the earlier result. The history rules and patient session model are reused. This is a check in the same patients. It is not an independent replication.

  4. usesdoi:10.18112/openneuro.ds004752.v1.0.1

    Source dataset, version 1.0.1; its CC0 metadata and source URL are preserved in the package.

  5. supportsdoi:10.7554/eLife.78677

    Source paper for the task timing, load rule, clinical sample, and task context described in the publication.

  6. doi:10.1038/s41593-020-00744-x

    Background for distinguishing fixed-band power from wider spectral changes; the paper motivates the question, and its spectral peak fitting code was not used.

Cited by

2 publications

Public catalog entries on Sciscape.