The prior-load estimate for adjusted hippocampal theta change included zero in 14 SEEG patients

This exploratory study tested whether previous loads of eight versus four letters were associated with adjusted hippocampal theta change from fixation to final maintenance. It used public OpenNeuro ds004752 v1.0.1. The primary model used 2,561 trials in 62 sessions from 14 patients after correct prior responses. It controlled current load and separate linear session trends. Each patient had equal group weight. The stored-reference mean was -0.042 dB, with a 95 percent patient bootstrap interval of -0.325 to +0.225 dB. The exact two-sided patient sign-flip p value was 0.778076. The primary interval included zero. The evidence did not establish a group association under this model. It did not show that the association was absent. The package preserves new equal one-second spectra, source versions, raw test fixtures, code, exact model inputs, resampling draws, results, and reproduction instructions. The fixed spectral residual does not isolate a physiological theta rhythm. The study uses the same patients as the cited fixation work. It is not an independent replication.

hippocampus · intracranial EEG · theta power · working memory · memory load · spectral analysis · patient-level inference