OpenNeuro electrode coordinates do not verify the within-shaft SOZ result for 728 archived bipolar pairs

A prior analysis reported mean per-patient AUCs of 0.72 for NREM 80–300 Hz power and slow-wave/HFA coupling when seizure-onset-zone (SOZ) bipolar pairs were grouped by contact-name prefix, described as a shaft. We compared 728 archived pairs from 43 patients with public OpenNeuro electrode coordinates to assess whether this result could be verified within physical shafts. Coordinates were missing for 606 pairs (83%), including 147 of 160 SOZ pairs (92%); 33 patients had no analysed pair with coordinates. For the 122 pairs with coordinates, archived pair distances agreed with the electrode file within 0.1 mm. A preregistered 10 mm consecutive-contact rule left only one patient with both SOZ and non-SOZ pairs on a verified shaft (AUC 0.667 for each marker; Holm-adjusted p = 1.0, n = 1). The same limitation held at 7 mm and 15 mm. The prefix-based results reproduced (mean AUC 0.719 for log HFA and 0.718 for coupling across 41 patients), but the available files support a comparison within name prefixes, not a verified comparison within physical electrodes. This does not show that either marker fails. The analysis used fsaverage coordinates only; it did not inspect channels.tsv status or EDF files, the cause of missing coordinates is unknown, and the fixed distance rule is not validated against ground-truth shaft labels.

intracranial EEG · electrode coordinates · seizure onset zone · high-frequency activity · slow-wave coupling · OpenNeuro · reproducibility