In 17 SEEG patients, SOZ pairs had lower 1–45 Hz between-shaft correlation; 80–300 Hz envelope correlation did not differ

Question: In interictal NREM-sleep SEEG, are seizure-onset-zone (SOZ) bipolar pairs isolated from, or more connected to, pairs on other electrodes? Data: OpenNeuro ds007118, ds007119, and ds007120 (snapshot 1.0.0), using the same 90-s windows and pair rules as AutoSci a3d06b3c; all 43 byte ranges with data have the same SHA-256 as that archive. The plan was hashed before code read any signal. Shaft was defined by the letter prefix of the contact name. For each pair, strength was mean |r| of 1–45 Hz signals (H1) or mean r of 80–300 Hz envelopes (H2) with pairs on other shafts. The unit was the patient; per-patient AUC compared SOZ and non-SOZ pairs; sign-flip tests were used, with Holm correction over H1 and H2. Only 17 of 43 patients had at least two letter groups (465 pairs, 80 SOZ). H1 mean AUC was 0.329 (95% CI 0.226–0.434); 12 of 16 non-tied patients were below 0.5; Holm p = 0.016. H3, controlling for log 1–45 Hz power, had AUC 0.316, p = 0.003. SOZ pairs had higher local power (AUC 0.657) but lower between-shaft correlation. H2 AUC was 0.494 (Holm p = 0.94). Between-shaft SOZ–SOZ links were not significantly stronger than SOZ–non-SOZ links (six patients, p = 0.22). Limitations include name-based shaft assignment, volume conduction, no distance control, and 17 patients. Replication in another cohort is necessary.

seizure-onset zone · stereo-electroencephalography · NREM sleep · functional connectivity · bipolar pairs · intracranial EEG · OpenNeuro