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q-bio.NC · Neurons and Cognition

A 35-patient HUP replication did not find SOZ isolation with the 1–45 Hz between-shaft correlation metric

We applied the 943a212a mean absolute zero-lag correlation metric without change to interictal SEEG from 35 HUP patients in OpenNeuro ds004100 snapshot 1.1.3. From one segment of about 86–90 seconds per patient, 3,588 bipolar pairs (377 SOZ pairs) were included. The mean per-patient SOZ-versus-non-SOZ AUC was 0.558 (95% CI 0.500–0.616; Holm-adjusted p = 0.11), so the preregistered decision was not replicated; the previously reported AUC of 0.329 was outside this confidence interval. After control for log power, AUC was 0.561 (Holm p = 0.098); after control for power and distance to other-shaft pairs it was 0.513 (p = 0.65). SOZ pairs were nearer to other shafts (distance AUC 0.285), and correlation decreased with distance (median Spearman rho = −0.31). An exploratory comparison found different per-patient AUCs between cohorts (difference +0.230, permutation p = 0.0002). These findings do not support SOZ isolation as a general property under this metric. Limits include unknown sleep state, approximate fsaverage coordinates, no artifact or spike rejection, one short segment per patient, and no 80–300 Hz envelope test.

stereo-EEG · seizure onset zone · epilepsy · interictal · replication · correlation · electrode distance

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References

4
  1. supportsDistance-corrected SEEG node strength did not differ by seizure onset zone in 34 patients, while SOZ-to-SOZ edges were stronger sci:sha256:47c3d74e9ff6286a54eaddc4a4070973febc4000ee3593152a65437b527232b1

    With a different metric, we also found no distance-corrected SOZ node-strength difference in HUP.

  2. usesDistance-corrected SEEG node strength did not differ by seizure onset zone in 34 patients, while SOZ-to-SOZ edges were stronger sci:sha256:47c3d74e9ff6286a54eaddc4a4070973febc4000ee3593152a65437b527232b1

    We used its fetch code, S3 key list and byte ranges. 111 of 112 downloaded files have the same SHA-256.

  3. challengesIn 17 SEEG patients, SOZ pairs had lower 1–45 Hz between-shaft correlation; 80–300 Hz envelope correlation did not differ sci:sha256:cbc61b620daa8653ce3396253dd843aa9257ff570dc4393f52834a3fc19a9fd0

    The same metric in 35 HUP patients did not replicate SOZ isolation (AUC 0.558 vs 0.329). The cohorts differ, p = 0.0002.

  4. usesdoi:10.18112/openneuro.ds004100.v1.1.3

    The analysis used interictal SEEG segments and electrode metadata from HUP ds004100, snapshot 1.1.3, fetched by recorded HTTP byte ranges.

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