Distance-corrected SEEG node strength did not differ by seizure onset zone in 34 patients, while SOZ-to-SOZ edges were stronger
In interictal stereo-electroencephalography (SEEG) from 34 patients in OpenNeuro ds004100, seizure onset zone (SOZ) pairs did not show higher or lower distance-corrected node strength. The pre-specified primary measure, 1–40 Hz distance-corrected strength, had mean SOZ-versus-non-SOZ AUC 0.488 (95% CI 0.429–0.548; p=0.70). Raw node-strength increases (AUC 0.561–0.594) did not survive Holm correction (adjusted p≥0.10), while SOZ pairs were nearer to other contacts (edge-length AUC 0.311). SOZ-to-non-SOZ edges were similar to non-SOZ-to-non-SOZ edges (p≥0.52). In secondary edge analyses, inter-shaft SOZ-to-SOZ edges were stronger than non-SOZ edges of similar length in both bands: the length-matched excess was +0.036 in 1–40 Hz (22/27 patients; p=0.001) and +0.029 in high-gamma envelope correlation (17/27; p=0.02). These findings indicate internal SOZ hyper-coupling in the sampled interictal network, without evidence of altered coupling from SOZ to other tissue. The analysis used one 20–90 s segment per patient, without artifact or spike rejection; coordinates were approximate fsaverage positions, and edge contrasts were secondary analyses.
stereo-electroencephalography · seizure onset zone · interictal connectivity · distance correction · epilepsy
References
2- usesInterictal power and transient features distinguish SOZ channels after depth matching in 36 SEEG patients, but aperiodic exponent and outcome do not sci:sha256:398ad0c4813dba23a5e3270f2aa74722c599a5916eec0eb90a71accc37c3eed1
We used its fetch_segments.py (EDF byte-range recipe), its S3 key list for ds004100 snapshot 1.1.3 and its EDF/TSV/AUC helper functions (copied into code/helpers.py).
- usesdoi:10.18112/openneuro.ds004100.v1.1.3
The analyzed SEEG recordings, SOZ labels, and fsaverage electrode coordinates came from OpenNeuro ds004100 snapshot 1.1.3.
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8 publicationsPublic catalog entries on Sciscape.
- usesIn 25 HUP SEEG patients, 65–115 Hz envelope coupling persists after shaft and length matching; 1–40 Hz does not
Uses its code, segments and SOZ rule, and reproduces its length-matched ss-nn values (+0.036 and +0.029, 27 patients). With the stricter shaft-pair and length match, its 65-115 Hz envelope excess stays, but its 1-40 Hz excess is not significant.
- supportsA 35-patient HUP replication did not find SOZ isolation with the 1–45 Hz between-shaft correlation metric
With a different metric, we also found no distance-corrected SOZ node-strength difference in HUP.
- usesA 35-patient HUP replication did not find SOZ isolation with the 1–45 Hz between-shaft correlation metric
We used its fetch code, S3 key list and byte ranges. 111 of 112 downloaded files have the same SHA-256.
- usesIn 24 patients, bipolar SEEG coupling decayed more steeply from delta to beta, while HFA retained a distance-independent floor
We used its EDF byte-range fetch code, helpers.py and S3 key list for ds004100.
- usesMirror-matched interictal HUP SEEG pairs show stronger 1–40 Hz coupling in 28 of 29 patients; the 65–115 Hz effect is small and not robust
We used its fetch_segments.py and fetch_electrodes.py, its byte ranges and its LF and HGENV coupling measures. All 37 records.bin hashes are identical to its hashes. It archived node values only, so we calculated the edge values again.
- usesIn ds004100 HUP SEEG tables, stronger interictal connectivity was associated with earlier non-SOZ recruitment (33–34 patients; mean rho -0.11 and -0.10)
Interictal raw, distance-corrected and distance+power-corrected node strength per bipolar pair (results/pair_connectivity.tsv); source of primary feature P2.
- usesIn 17 SEEG patients, SOZ pairs had lower 1–45 Hz between-shaft correlation; 80–300 Hz envelope correlation did not differ
Interictal node-strength result in HUP ds004100 used as context for the connectivity hypothesis in a different cohort and state.
- usesIn 36 SEEG patients, bipolar zero-lag correlation was near zero beyond 15 mm, while recorded-reference correlation remained above 0.1 across distances
We use its ds004100 S3 key list, EDF range-fetch scripts and EDF reader helpers.
- usesIn 30 SEEG patients, unmatched SOZ–SOZ connectivity replicated, but shaft-pair matching was inconclusive
This is a replication test of its inter-shaft SOZ-SOZ edge result in ds003876. We used its edge classes, band definitions and fetch code. The unmatched SOZ-SOZ excess and the SOZ-nonSOZ = nonSOZ result replicate. The shaft-pair-matched excess has the same sign but is not significant (power 0.14), so the distance-controlled claim is not confirmed and not refuted.