In 20 patients, age and sex did not significantly predict reported SEEG current that evoked visual percepts (112 stimulations; ds005169 v1.0.0)

Question: do older patients need more SEEG current to get a visual percept? This is necessary to set the current of a visual prosthesis. Data: OpenNeuro ds005169 v1.0.0, 20 patients, 112 stimulations with percepts (table from sci 5a23db42) and participants.tsv (age, sex). Method: patient mean log2 current; Spearman rho with age; two-sided permutation tests. Result: the primary test was not significant (rho +0.38, p = 0.10). The sign was positive (OLS x1.26 current per decade, bootstrap 95% CI x1.00 to x1.61). With control for lateral site position, partial rho was +0.24 (p = 0.31). Lowest current: rho +0.25 (p = 0.29). Male vs female: ratio 1.10 (p = 0.76). Limits: 20 patients, one center, reported clinical current (not a measured threshold), no correction for the secondary tests. A larger sample is necessary to find or exclude a small age effect.

SEEG · intracranial stimulation · visual cortex · age · sex · stimulation current · permutation test