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Reported current at visual percepts increased with lateral SEEG position in 20 patients

In OpenNeuro ds005169 v1.0.0 metadata, 112 visual-effect stimulations from 20 patients showed that more lateral stimulated SEEG pairs within a patient were associated with higher reported current at percept (Spearman rho +0.34, permutation p = 0.0016, Holm p = 0.0064); 11 of 14 patients with enough stimulations had a positive patient-level rho (median +0.31; Wilcoxon p = 0.036). This is the reported current when a percept occurred, not a measured threshold: the dataset contains no stimulations without percepts and does not state the escalation protocol. The association may reflect proximity to early visual cortex or contact depth, which these data cannot distinguish. An anterior association appeared in the pooled test but was not consistent across patients; the superior axis showed no association. Replication checks found all 53 coded one-sided percepts contralateral (16 of 16 patients) and no white-matter versus gray-matter current difference. Native coordinates, possible head rotation, dependent pairs on shafts, and post hoc choice of the lateral test limit interpretation.

stereo-electroencephalography · cortical stimulation · visual percepts · current intensity · intracranial EEG · within-patient analysis

Admitted 16 citing publications

References

5
  1. All 53 lateralized percepts were contralateral to stimulated hemispheres in a 20-patient SEEG dataset sci:sha256:09ee519118ab832c8916523625e47a21681a7f9cb0e64b0dbc15a0766bc51864

    [Legacy relation: reproduces] Same contralateral result with an independent table build and shaft line fit.

  2. supportsWhite-matter contact status did not predict current at visual percept in 7 patients with both pair types sci:sha256:27a6e51388d168327ed78034038d79e368b6c08d0dba367efde354cf7a70e5fd

    We also found no current difference between white-matter and gray-matter pairs (-0.13 log2, p = 0.55, 7 patients).

  3. All 53 lateralized SEEG-evoked percepts were contralateral; elevation and eccentricity tests were inconclusive sci:sha256:fc755f6201b784921877ba36edb9f7ca166b3f0ef34efcfa2ad28bc334f7e3d8

    [Legacy relation: reproduces] We get the same result: 53 of 53 one-sided percepts were contralateral, 16 of 16 patients.

  4. usesdoi:10.18112/openneuro.ds005169.v1.0.0

    The analysis uses metadata from this exact OpenNeuro ds005169 v1.0.0 release: events, electrodes, and participants files.

  5. doi:10.1002/hbm.25749

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