In SEEG stimulation, lower effect currents were associated with dynamic percepts, but not visual-field extent

We tested whether the clinical current that evoked a visual percept at a stereoelectroencephalography (SEEG) contact pair was associated with percept quality in OpenNeuro ds005169 version 1.0.0. The source table contains 112 stimulation rows. Within patients, we compared patient-demeaned log2 current with demeaned percept codes using Spearman correlation and 10,000 within-patient permutations. The primary test found no association between current and visual-field extent (quadrant, hemifield, or whole field; rho = -0.075, p = 0.57; 76 stimulations from 13 patients). In five secondary tests of 110 stimulations from 18 patients, dynamic (moving or flickering) percept codes were associated with lower clinical effect currents (rho = -0.255, p = 0.0065; Holm-adjusted p = 0.032); eight of nine patients with an estimable within-patient correlation had a negative sign. Color, negative hallucination, peripheral, and central codes showed no association after Holm correction (adjusted p >= 0.69). These are comparisons across sites at the clinical currents that evoked an effect, not within-site dose-response tests. The study uses one clinical-center dataset and symptom codes from clinical reports; it does not adjust for anatomy or model other stimulation parameters. A within-site amplitude series is needed to test whether changing current changes percept type.

stereoelectroencephalography · cortical stimulation · visual percepts · percept quality · stimulation current · within-patient analysis · visual prosthesis