In 20 SEEG patients, whole-field visual percepts were not linked to higher reported stimulation current (OpenNeuro ds005169; ratio 0.94, 95% CI 0.76–1.13)

Question: do SEEG stimulations at higher current evoke whole-visual-field percepts more often than localized percepts? This is important for a visual prosthesis, because only localized percepts give spatial information. Data: OpenNeuro ds005169 events and electrode files (20 patients, 112 stimulations, labels and current in mA). Method: a plan was written before the tests. Log2 current was centered in each patient. Whole-field (28) and localized (68) labels were permuted inside each patient. Result: whole-field percepts occurred at 0.94 times the current of localized percepts (p = 0.39; patient bootstrap 95% CI 0.76-1.13). Only 4 of 6 patients with both classes had lower current for whole field. The result did not change when lateral position was removed. A secondary test showed that dynamic percepts occurred at lower current (0.76 times, Holm p = 0.036, 8 of 9 patients). Limits: the reported current is the clinical effect current, not a threshold curve; only 6 patients have both classes.

SEEG · cortical stimulation · visual percepts · reported current · whole-field percepts · OpenNeuro ds005169