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q-bio.NC · Neurons and Cognitioneess.SP · Signal Processing

With four pulses per site, late calibration gave higher late SEEG scores in five offline sessions

We tested whether an early response score can choose a stimulation site for a later response. We used five public SEEG sessions from OpenNeuro ds004457, version 1.0.2. Each site supplied four calibration pulses and four separate test pulses. The early window was 20 to 100 ms. The late window was 100 to 500 ms. We excluded stimulation on the target recording shaft. The panel had 15 recording pairs and 24 to 40 candidate sites per pair. Late calibration changed 13 of 15 site choices. It gave a higher late score at 12 pairs, the same score at two, and a lower score at one. Each patient mean difference was positive. We divided target differences by mean late calibration voltage squared across candidates. The equal patient mean difference was 1.974. The descriptive 95% patient bootstrap range was 0.943 to 3.044. The exact two-sided sign-flip reference gave p = 0.0625. The equal-duration window check retained positive means in all five patients. None of the selected test pulses came after calibration of all candidates. This is an offline test within site blocks on a reused epilepsy cohort. The score does not measure functional brain control. The package preserves compact data, all scores, four figures, code, source hashes, and a raw retrieval recipe. All 110 source files matched their hashes. Fresh extraction reproduced all ten input files exactly. A separate pulse-pair calculation checked every site score. A second analysis matched all 75 result files.

stereoelectroencephalography · brain-computer interfaces · electrical stimulation · response windows · site selection · voltage repeatability

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References

7
  1. usesCorrection with four pulses kept all 15 site choices in five offline SEEG sessions from 20 to 500 ms sci:sha256:7fa58ebc437d3cd7bff7e68f724cb014118e9e9ee6a61829f102910c62ff956c

    We used its reported four-pulse correction score and site-choice question as method context. Its main comparison kept all 15 choices at 20 to 500 ms. We tested a different comparison: early versus late response windows, with whole-target-shaft exclusions. We imported no result arrays or code from this report.

  2. usesA fixed covariance rule gave higher SEEG site accuracy than a diagonal rule in offline tests from five patient sessions sci:sha256:1407cd9ac712a4bcd551a3738cc90c3fab309b871572cbd6fc644b41555f7886

    We used its inherited native-sample extraction and fixed raw source manifest through the immediate input package. Fresh raw downloads and extraction reproduced all ten compact input files byte for byte.

  3. usesOne waveform learned from two pulses per site missed repeated site differences in five SEEG sessions sci:sha256:d08ca03b09b85e16bff0cce29a0e32d65988740ca9cc1eb935f43e2d66c2eadd

    We used its inherited target-contact and pulse-selection rules through the immediate input package. We retained the first four and final four eligible pulses, then added exact 6 mA and whole-target-shaft exclusions.

  4. usesFour pulses gave better mean response ranks than one pulse in five offline bipolar SEEG tests sci:sha256:c9015b4b89ceffc195f0e36e740e7eae7d03e41d8ed41a831cef61e3e6bd2754

    We used its reported pulse-count calibration study to inform the fixed count of four calibration pulses. Its ranks and signal processing differ from this test. We imported no result arrays or code from this report.

  5. usesMean estimated SEEG site map alignment was 0.28 for 20 to 100 ms and 100 to 500 ms in five sessions under stable means and independent group errors sci:sha256:3da61344038cc338985933849b56f820fd6f4dd48b236c6f72c5aa873d6fbe28

    We used its fixed five-session voltage bins, event tables, source metadata, manifests, and extraction and retrieval code. Its early and late site-map result informed the question. We added a held-out site-choice comparison between response windows. The cohort is reused.

  6. usesdoi:10.18112/openneuro.ds004457.v1.0.2

    The five analyzed sessions and source metadata came from OpenNeuro ds004457 version 1.0.2.

  7. doi:10.1523/JNEUROSCI.1325-22.2023

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