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A 25 ms search raised window AUC under uniform simulated ±25 ms errors at 86 sites in eight SEEG sessions

We tested a time search for reading late windows after a known stimulation pulse. We used public SEEG data from OpenNeuro ds004696 version 1.0.1. The test retained 86 fixed recording pairs in eight clinical sessions. At each site, five early pulses fitted a signed template. Five later pulses tested the reader. Target windows had strict 125 to 375 ms bounds. The main test enumerated uniform simulated clock errors from -24.90 to +24.90 ms. Search used the same bounds for pulse and background windows. AUC is the area under the receiver operating characteristic curve. The equal-patient mean AUC rose from 0.8498 to 0.8733. The mean paired gain was 0.0235, with a descriptive 95% bootstrap interval of 0.0103 to 0.0361. Seven of eight patient means increased. Energy AUC was 0.8726. A post hoc paired comparison did not show a clear search advantage over energy. At exact timing, the same search increased mean AUC by 0.0183. Thus the full gain cannot be assigned to clock error recovery. Searching pulse windows only gave diagnostic AUC 0.9101 because background processing differed. The package includes selected data, exact scores, four figures, source audits, exact result files, and source records. This is an exploratory offline window test. Real clock faults, continuous commands, and stimulation benefit were not tested.

stereoelectroencephalography · SEEG · brain-computer interface · electrical stimulation · time search · clock error · AUC · signal energy

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References

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  1. usesA fixed spatial noise rule gave no clear 20 to 500 ms AUC gain after five early pulses in eight SEEG sessions sci:sha256:48f93098d9fe4ee439817f49e745f4c586103d8b79d4985cbb51b1bf7dc5d020

    Its signed template reader and patient-level AUC supplied method context. The current study uses fixed inherited pairs, a central late window, explicit time-error mixtures, and a matched search. All scores were calculated again.

  2. usesAfter five calibration pulses, about 25 ms template offsets gave a 7.48% mean patient error increase in 100–500 ms SEEG forecasts across eight sessions sci:sha256:949831979a0945dfe30f29a37ca4d255ab1dab3c525ac796fa997f1a4a3ed170

    Its test of template time offsets motivated the clock question. We tested a different endpoint: late pulse/background AUC under uniform simulated errors with a matched time search. The current result is not a replication of its waveform forecast endpoint.

  3. usesEight donor shapes reduced five-pulse SEEG forecast error versus eight cosines at 86 selected sites in eight patients; full waveforms had less error sci:sha256:d5f05d9adcd5c0419c50f10231ba2502cf7acc24728e09a3c09631e52e5a88e3

    This publication supplied the exact 86 selected voltage files, pulse maps, fixed recording pairs, source metadata, and source retrieval code lineage. We fitted new templates and calculated new time-search scores. We did not reuse forecast scores.

  4. usesdoi:10.18112/openneuro.ds004696.v1.0.1

    The study uses selected trial voltage derivatives and pulse records from OpenNeuro ds004696 version 1.0.1.

  5. supportsdoi:10.1523/JNEUROSCI.2201-22.2023

    This source study reported late response shapes in the human limbic system, motivating the late window; it does not establish that all voltage in the tested window is neural.

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