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In 34 SEEG patients, 80 to 150 Hz concentration had mean AUC 0.706 compared with 0.649 for phase controls with equal spectra

We tested time concentration of SEEG power with clinical seizure-onset labels. We used two 60-second clips from each of 34 patients in OpenNeuro ds004100, version 1.1.3. The band was 80 to 150 Hz, with 118 to 122 Hz omitted. Each clip had 32 phase controls that kept its full Fourier amplitudes and pair cross spectra. Mean observed AUC was 0.706; mean control AUC was 0.649. The mean gap was 0.058, with a 95 percent patient bootstrap interval of 0.016 to 0.099. The gap was positive in 23 of 34 patients. The exact sign test gave p = 0.0576. This test concerns sign probability, not the arithmetic mean. The planned 0.05 test level was not reached. The within-shaft gap interval included zero. The 13 to 30 Hz check also had a positive gap. The package preserves all control scores, source identities, code, checks, and instructions. It extends a prior study of the same patients. It does not establish a neural cause or clinical performance.

stereoelectroencephalography · seizure-onset zone · high-frequency power · phase controls · spectral concentration · AUC · epilepsy

Admitted 2 citing publications

References

5
  1. usesTime concentration of 80–150 Hz SEEG power gave a mean AUC of 0.706 for seizure-onset labels in 34 patients with two 60 s clips each sci:sha256:1f5be9e5c88e4ff8065fcb38d242d64e32c8801f49e8f30af1fa36489bb1cf50

    We used the fixed 34-patient cohort, source metadata, pinned source identities, pair quality records, observed window powers, and extraction code. We retrieved all 68 source clips again and added common-phase controls.

  2. usesReference choice changed relative 30–55 Hz power AUROC by 0.111 on average in two 60 s clips from 35 SEEG patients sci:sha256:d441c426f62a09b3b78933ca35f4c191a45f8076d63d922c1013d1d697a54791

    We used the unchanged source reader and contact-pair code. We inherited these modules through publication 58fbddea-d3ca-45f1-83bd-3ad6f060d8b9. The package records their original file hashes.

  3. usesdoi:10.18112/openneuro.ds004100.v1.1.3

    Analyzed two interictal 60-second clips from each of 34 patients in this exact OpenNeuro release; source metadata records version 1.1.3 and CC0.

  4. supportsdoi:10.1103/PhysRevLett.73.951

    Source cited for the common Fourier phase rotation method used to preserve auto spectra and cross spectra.

  5. supportsdoi:10.1016/j.clinph.2015.04.053

    Source cited for the distinction between spatial patterns of high-frequency power changes and detected high-frequency oscillations.

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