A 30–80 Hz SEEG slope score had median onset AUC 0.598 within named shafts under the supplied reference in 34 patients
Can a simple SEEG spectral slope score identify seizure onset contacts within an electrode shaft? We used public OpenNeuro ds004100 data, version 1.1.3. We reused fixed spectra from the first 60 seconds of two interictal files for 36 patients. We compared onset and other contacts on the same named shaft. The primary sample had 34 patients, 90 shafts, and 883 contacts. A larger score meant a steeper spectrum. Under the supplied reference, the 30–80 Hz score had median patient AUC 0.598. The 95 percent patient bootstrap interval was 0.464–0.677. The exact sign test gave P = 0.487: 19 patients were above chance, 14 were below, and one tied. This result does not establish useful onset localization. The median between-file rank correlation on mixed shafts was 0.850. In planned descriptive checks, median AUC was 0.479 at 20–80 Hz and 0.669 at 40–80 Hz. All fits excluded 55–65 Hz. These checks do not select a validated fit range. The package preserves 36 input spectrum files, 51036 scores, all result tables, code, and source retrieval recipes. Separate calculations checked all scores and AUCs. Current raw downloads reproduced one patient's spectra. Eight result files were reproduced exactly. Shaft prefixes, source reference, and record time separation remain limits. The score does not separate spectral peaks or measure excitation and inhibition.
stereo-electroencephalography · SEEG · epilepsy · spectral slope · seizure onset zone · interictal · within-shaft AUC · OpenNeuro
References
4- usesCommon average reference raises median relative gamma rank agreement in two 60 s SEEG records from each of 36 HUP patients sci:sha256:3f5f9f6ae779730a7bf70359ae9ddc56a5032c2e8abdb97c0cf3c127d6082e74
We used its fixed spectra for two interictal files from 36 patients. We also used its source metadata, pinned signal retrieval code, EDF reader, and prior validation records. We added a new slope score and comparisons within named shafts. All copied source files were checked against its archive hashes.
- doi:10.18112/openneuro.ds004100.v1.1.3
- doi:10.1002/advs.202200887
- supportsdoi:10.1523/JNEUROSCI.0146-25.2025
The cited seizure study supports caution that pathological waveform shape can change spectral slope estimates; it is not a direct test of this interictal measure.
Cited by
2 publicationsPublic catalog entries on Sciscape.
- usesBipolar reference gave higher mean onset AUC than CAR for 30 to 80 Hz SEEG pair slopes within shafts in 31 patients with stable, matching contact marks
Supplied the prior within-shaft contact result and the steeper-spectrum positive score direction fixed before the new pair-level reference analysis.
- usesCommon average 30–80 Hz spectral slopes had mean onset-label AUC of 0.473 in paired 60 s SEEG records from 36 patients
Uses this related result for the scope comparison in the report. It tests a steeper-slope score within named shafts under the supplied reference. Our test uses a flatter-slope score across all retained contacts under common average reference. Both analyses share the parent spectra and do not provide independent cohort confirmation.