Bipolar reference gave higher mean onset AUC than CAR for 30 to 80 Hz SEEG pair slopes within shafts in 31 patients with stable, matching contact marks
We tested how reference choice changes a fixed score of clinical seizure onset marks in public SEEG data. The source was OpenNeuro ds004100, version 1.1.3. The primary test used 31 patients, 71 named shafts, and 553 adjacent contact pairs. Each pair had stable, matching contact onset marks. A larger 30 to 80 Hz exponent was the fixed positive score. The fit removed 55 to 65 Hz. It did not separate spectral peaks. We compared pairs within the same shaft and gave each patient equal weight. The mean onset area under the receiver operating characteristic curve (AUC) was 0.656 with bipolar reference and 0.583 with common average reference. The paired mean gain was 0.073. Its 95 percent patient bootstrap interval was 0.007 to 0.138. The interval assumes independent, exchangeable patients and is conditional on selection. Nineteen patients gained AUC, nine lost AUC, and three tied. The exact sign test gave P = 0.087. All seven planned sensitivity checks had positive mean gains. The 20 to 40 Hz gain interval included zero. This retrospective rank test does not establish clinical benefit. The cohort and observations were reused. The package preserves spectra, source marks, retrieval recipes, code, pair and patient results, figures, and independent checks.
stereoelectroencephalography · seizure onset · spectral slope · bipolar reference · common average reference · area under the ROC curve
References
4- usesMean bipolar reference effects exceeded file differences for 30–80 Hz slopes in paired 60 s SEEG records from 36 patients sci:sha256:a343645ba027d704e981c68fea0352745ba1410c491d9bbbcc42ef099ff50447
Supplied all 36 paired spectrum archives, source metadata, retained contact lists, adjacent pair maps, frozen raw hashes, and the retrieval and spectral code used in the new onset rank comparison.
- usesA 30–80 Hz SEEG slope score had median onset AUC 0.598 within named shafts under the supplied reference in 34 patients sci:sha256:b1540e7ea5e7e85e110d7fc95f44a4ca2b09fd269cadc931de598e8caf1f3f94
Supplied the prior within-shaft contact result and the steeper-spectrum positive score direction fixed before the new pair-level reference analysis.
- usesCommon average 30–80 Hz spectral slopes had mean onset-label AUC of 0.473 in paired 60 s SEEG records from 36 patients sci:sha256:9fd58699b965345c851b5361a87b4b86fb623db5b74a0d38c20a5039bde188a3
Supplied the earlier CAR contact rank result. Its different score direction, contact unit, and across-shaft pool helped define the new paired reference question and its scope.
- usesdoi:10.18112/openneuro.ds004100.v1.1.3
Source SEEG dataset used for the patient records, contact marks, and spectral analysis; the analyzed source release is version 1.1.3.
Cited by
2 publicationsPublic catalog entries on Sciscape.
- usesEqual window power reduced file disagreement but did not establish better seizure onset label ranking in 31 patients
This source supplied the fixed clinical label selection, within-shaft AUC hierarchy, and larger-is-positive score direction. The present secondary analysis reuses its primary eligible patients and reproduces its raw bipolar AUC. It adds the contrast with equal window power.
- usesWindow power normalization gave an onset AUC change interval that included zero for 30–80 Hz bipolar SEEG in 31 patients
We used its stable endpoint label rule and within-shaft AUC rule. Its contact labels and ordinary bipolar AUC results supplied independent reference checks. The current test adds the window normalization comparison.