Individual 4-13 Hz SEEG peak frequency does not predict free-recall rate in 260 RAM epilepsy patients (FR1 and catFR1 session 0, task-period bipolar spectra, partial rho -0.01, 95% CI -0.14 to 0.11)
We tested whether a subject-level 4-13 Hz spectral peak frequency from bipolar stereoelectroencephalography (SEEG) predicted free-recall rate in 260 epilepsy patients from session 0 of RAM FR1 and catFR1. The peak values came from archived spectra computed over 60 s beginning at the first word event; recall rates were calculated from 261 event files, each of which matched its archived SHA-256. A preregistered partial Spearman test adjusted for site, sampling rate, sex, log number of electrode pairs, dataset, and age. The association was near zero (rho = -0.012, 95% CI -0.140 to 0.113, permutation p = 0.85); the confidence interval excludes associations larger than |rho| = 0.14. Peak height, relative 8-12.5 Hz power, 7-13 Hz peak frequency, aperiodic exponent, and fraction of pairs with a peak also showed no association after Holm correction (all adjusted p >= 0.65). The result was similar in FR1 only, catFR1 only, and several sensitivity analyses (all p > 0.5). As a positive control, age was associated with recall rate (rho = -0.232, p = 0.0003). These results provide no evidence that task-period bipolar SEEG peak frequency predicts recall rate in this sample. The study concerns epilepsy patients, one session per patient, and 60 s of task-period encoding data; bipolar SEEG peaks are not the same measure as the posterior scalp alpha peak at rest.
stereoelectroencephalography · free recall · memory · spectral peak frequency · individual alpha frequency · FR1 · catFR1 · partial Spearman correlation · epilepsy
References
3- usesIn 261 RAM SEEG subjects aged 18–64, 4–13 Hz peak frequency did not decrease with age, while peak height and relative alpha power increased sci:sha256:0e36e73fa7707bba416e7d46869f09378b140e05e39d6e785874fd9baeda4c32
Per-subject 4-13 Hz peak values, spectral metrics and provenance (events.tsv URLs and SHA-256) are reused without change.
- usesdoi:10.18112/openneuro.ds004789.v3.1.0
Session-0 FR1 events.tsv files were used to calculate subject-level recall rates. The recorded source is OpenNeuro ds004789 v3.1.0.
- usesdoi:10.18112/openneuro.ds004809.v2.2.0
Session-0 catFR1 events.tsv files were used to calculate subject-level recall rates. The recorded source is OpenNeuro ds004809 v2.2.0.
Cited by
3 publicationsPublic catalog entries on Sciscape.
- usesMore left-sided SEEG implantation was associated with lower verbal recall in 254 RAM patients
Subject table with session-0 recall rates, age, sex and site.
- usesLeft extratemporal coverage was associated with lower recall in RAM SEEG patients, while temporal coverage was not
Source of the session-0 recall rates, age, sex and site.
- supportsNeither single frequencies (1–45 Hz) nor a full-spectrum ridge model predicted session-0 free recall from task-period SEEG in 261 RAM patients
Its null result for 6 fixed spectral features extends to all frequencies from 1 to 45 Hz and to a full-spectrum ridge model.
- usesNeither single frequencies (1–45 Hz) nor a full-spectrum ridge model predicted session-0 free recall from task-period SEEG in 261 RAM patients
The session-0 recall rates and the covariate set come from this work.