At a 20 ms pulse interval, date means showed earlier second fitted onset in 24 mouse S1 recordings with current depression
We tested whether a smaller second current must have a later onset. We used released mouse cortical data with a 20 ms pulse interval. The main table had 130 layer 2/3-to-layer 5 pathway recordings on 64 dates. In 24 young sensory cortex recordings with current depression, the mean second-minus-first fitted onset per date was -0.217 ms. Its 95% date bootstrap range was -0.345 to -0.095 ms. In 44 young lateral prefrontal recordings with facilitation, the change was -0.149 ms, with a range of -0.246 to -0.052 ms. Two date sign-flip tests gave Holm reference p values of 0.00577 and 0.00770. Raw current ratios, quality filters and a short first-current decay rule retained earlier means. A separate set of 41 prefrontal layer 5 paired recordings also gave earlier second onset. The main result gives a case where current depression occurred with earlier fitted onset. It limits a timing rule that always assigns later onset to a smaller second response in this measured pathway. It does not identify the cause. Minimal extracellular stimulation can recruit several axons. Complete current traces, presynaptic spike times and verified animal identities were absent. The study does not measure channel geometry or second-pulse timing variability. We supply both source workbooks, checked tables, source hashes, code, figures, all pooled resampling draws and offline repeat instructions. A clean repeat matched all 13 numerical output files.
synaptic timing · short-term plasticity · structure and function · paired pulse · somatosensory cortex · prefrontal cortex · release timing · reproducible analysis
References
5- usesdoi:10.7554/eLife.110314.3
We use Figure 1 source data 1 and 2, version 1, for a new within-recording pulse onset analysis.
- doi:10.1016/j.neuron.2007.10.037
This prior study links depression to later latency and facilitation to earlier latency in cortical and hippocampal recordings.
- doi:10.1113/jphysiol.2010.199653
This prior study shows that presynaptic action potentials can change synaptic timing.
- doi:10.3390/cells13070573
This prior study shows that another form of facilitation can occur without a delay change.
- In 126 mouse layer 5 recordings, a log model gave a prefrontal versus sensory delay SD ratio of 1.28 after response controls sci:sha256:c11cfd5420dc4a1e5f4f69022ffd40109767a03ac776166d18737ce9706e589e
This related source audit and timing study concerns first-pulse variability. Our new contrast uses the first and second fitted onsets in each recording.
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