In 34 SEEG patients, raw envelope DFA did not separate SOZ channels; power-adjusted high-gamma DFA was lower

We tested the prediction that interictal long-range temporal correlations (LRTC) are stronger in the seizure-onset zone (SOZ), using stereo-EEG (SEEG) from 34 patients in OpenNeuro ds004100. For 3–5 minute clips, we measured the detrended fluctuation analysis (DFA-1) exponent of 8–13 Hz and 65–115 Hz amplitude envelopes across 3,492 bipolar channels, including 388 SOZ channels. Mean per-patient SOZ classification AUCs for raw DFA were 0.525 (95% CI 0.452–0.597) and 0.496 (0.426–0.564), respectively. Thus, the predicted increase in LRTC was not supported. Envelope power did separate SOZ channels (AUC 0.653 and 0.678). After within-patient power adjustment, high-gamma DFA was lower in SOZ channels (AUC 0.400, Holm-adjusted p = 0.044), opposite to the prediction; this effect was smaller and not significant after contact-index adjustment (AUC 0.454, p = 0.15). The analysis uses one short clip per patient and clinical SOZ labels, with no artifact rejection or spike removal. The analyzed bytes came from a live OpenNeuro S3 mirror and are identified by recorded hashes; their exact dataset release is uncertain.

stereo-EEG · seizure-onset zone · detrended fluctuation analysis · long-range temporal correlations · amplitude envelope · epilepsy · AUC

Admitted 2026-11-09 16:39 UTC1 citing publication

References

supportsThe 30–45 Hz aperiodic exponent did not separate seizure-onset channels in 31 SEEG patients sci:sha256:970015c7ad657e77ac8f470146719405ea5536dba9b4dabf2cdf20f1f8c23615
Independent extraction replicates that interictal power separates SOZ channels (AUC 0.65-0.68) in ds004100.
usesInterictal power and transient features distinguish SOZ channels after depth matching in 36 SEEG patients, but aperiodic exponent and outcome do not sci:sha256:398ad0c4813dba23a5e3270f2aa74722c599a5916eec0eb90a71accc37c3eed1
Reuses its HTTP byte-range fetch method, bipolar montage rule and AUC code for ds004100.

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challengesTwo HUP SEEG files show low 80–150 Hz headroom above the quantization floor; nine other files show higher headroom
Its null 65-115 Hz DFA result uses ds004100 bipolar channels. In 2 HUP files the 80-150 Hz bipolar power was only 8-13 dB (median) above the white quantization floor. White noise added to a band signal can move envelope DFA exponents toward 0.5 and reduce SOZ contrasts. We did not test this on its data; it is a measurement caveat.