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The mean patient median energy change beyond baseline was -0.60 percent of the baseline scale in 176 SEEG blocks from five patients

We tested whether repeated electrical pulses changed signed waveform energy in public SEEG data. We used OpenNeuro ds004457 version 1.0.2. The analysis compared the first and second pulse halves. It subtracted the matching change before stimulation. The sample had five patients, 19 receiving contacts, 176 consecutive blocks, and 590 contact-block links. Each block had 8 to 18 retained good biphasic 6.0 mA pulses. The equal mean of patient median changes was -0.60 percent of the fixed patient baseline energy scale. The descriptive patient bootstrap 95 percent interval was -3.56 to +2.36 percent. The patient sign test gave p = 0.75. The conditional order test gave p = 0.8365, under joint pulse-label invariance. We proved an exact linear formula for balanced half energy differences. We checked all half scores with direct pulse products. The package preserves source epochs, raw retrieval code, source hashes, code, all link results, and null labels. Five patients, shared noise, and uncertain recording reference limit interpretation. The result does not prove stable responses or a neural cause.

SEEG · electrical stimulation · pulse order · waveform energy · signed energy · intracranial EEG · balanced-label test

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References

6
  1. usesInterleaved pulse splits gave an uncertain mean patient median SEEG correlation gain of 0.008 in five patients sci:sha256:0157822b95095ada37d6604011da4e5ea8517b34e4de08c81710f23a426e1f67

    The publication supplied epoch arrays, selected contacts, source locks, and retrieval and extraction code. We tested a different signed energy endpoint in the same five-patient cohort.

  2. usesAn energy correction changed the top contact at 13 of 152 SEEG sites with ten pulses in five patients sci:sha256:b04527db1eaa50be973bc86092f57cb0110775e6a99bb19657371f45869e67fd

    The publication supplied the signed distinct-pulse energy definition and its noise conditions. We used that definition for balanced chronological pulse halves. We wrote new code and used different windows and blocks.

  3. usesBaseline subtraction retained a pulse-count term in a fixed test of 1,081 SEEG links from five patients sci:sha256:c54ff982cb3901bbf39f5043ffe766192721b249eaad32d28a83cb826ecc0378

    The publication supplied the mean-energy and pulse-variance identity. It motivated the independent-noise model checks. Our new calculation compares chronological halves with equal pulse counts.

  4. usesdoi:10.18112/openneuro.ds004457.v1.0.2

    The analysis uses OpenNeuro ds004457 version 1.0.2; the source Git commit and file hashes are preserved.

  5. doi:10.1523/JNEUROSCI.1325-22.2023
  6. doi:10.1111/epi.17528

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