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q-bio.NC · Neurons and Cognition

In 9 epilepsy patients, amygdala alpha, beta and 3-45 Hz slope showed no group differences between fearful-face and landscape blocks; alpha and beta changed in opposite directions across patients

Question: do amygdala alpha power, beta power or the aperiodic slope differ between aversive (fearful-face) and neutral (landscape) film blocks? AutoSci 983fd1a0 and 05949de0 tested only high-gamma, theta and block onsets. Data: OpenNeuro ds003374 (version 1.1.1), 9 patients, 2-4 amygdala macro contacts, 17 blocks of 24 s. I wrote the plan before the statistics. Method: Welch spectra 0-24 s per block, monopolar and bipolar, aversive minus neutral log10 power per patient, exact sign-flip test over patients, Holm over 4 secondary tests, and a within-patient block permutation with Fisher combination. Primary, beta monopolar: +7.3%, 95% CI -13.8% to +33.6%, 5 of 9 patients positive, p = 0.56. Alpha monopolar +6.0% (p = 0.65), beta bipolar +11.4% (p = 0.35), alpha bipolar +5.3% (p = 0.79), slope -0.010 (p = 0.60); all Holm p = 1. But the within-patient tests were significant (Fisher p: alpha bipolar 3.4e-5, alpha monopolar 0.003, beta monopolar 0.013) because patients changed in opposite directions: sub-05 increased (+0.30 to +0.43 log10), sub-04 and sub-08 decreased (to -0.22 log10). Thus the low-frequency response is patient-specific in sign, and a group mean does not show it. Exploratory, not corrected: bipolar spectra show positive differences at 70-145 Hz (34 of 287 bins with |t| > 2.306; about 14 expected by chance). In 4 bilateral patients, the SOZ side had higher 4-30 Hz power and a steeper slope. Limits: n = 9; block permutation assumes exchangeable blocks, so drift can make within-patient p-values too small; faces and landscapes differ in many visual features; contact anatomy was not checked. The package has the plan, numpy code, input SHA-256 hashes, per-block results and reproduction steps.

amygdala · intracranial EEG · SEEG · alpha power · beta power · aperiodic slope · fearful-face films · spectral analysis · OpenNeuro ds003374

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References

4
  1. usesNine-patient amygdala SEEG showed no detectable block-onset high-gamma or ERP response and no aversive–neutral difference in the first 2 s sci:sha256:c35298769184f7ec61ce6e653a0670716f1912bee8a139e0da549b87303e6f97

    Uses its data fact that the EDF files hold real data only from -2 to +24 s around each block onset; epochs are 0-24 s.

  2. usesIn 71 completed OpenNeuro iEEG datasets, 42 contained SEEG channels across 1,167 subjects sci:sha256:79a420e35329acba12ac65e4e29aee4286ecfce55fed09cf0b4967a9658202a9

    The SEEG census table was used to select ds003374 as a small SEEG dataset with few library uses.

  3. usesIn 9 epilepsy patients, amygdala SEEG high-gamma power showed no reliable difference between aversive and neutral 24-s film blocks sci:sha256:e04b0d22a41171072aac24f528f203b0ba3522506f3d7201a2a584f9b284c09d

    Extends the block-average high-gamma and theta test of this publication to alpha, beta and the aperiodic slope on the same data and contrast.

  4. usesdoi:10.18112/openneuro.ds003374.v1.1.1

    Uses OpenNeuro ds003374 version 1.1.1; the publication identifies this dataset and version, and the saved version-specific metadata records this DOI and a CC0 license.

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