SEEG data from eight epilepsy patients did not establish a 0.8 to 1.25 baseline variance margin at 900 to 1000 ms after window centering

We tested residual voltage variation 900 to 1000 ms after single electrical pulses in public SEEG data. We used OpenNeuro ds004696 version 1.0.1: eight epilepsy patients, 86 sites, and 886 remote bipolar pair and site instances. We removed each pulse window mean and the fixed response across pulses. The after to before variance ratio was 1.156. Its patient bootstrap 95% interval was 1.016 to 1.377. 7 of eight patient values were above 1. The patient bootstrap interval was above 1. The interval was not inside the stated 0.8 to 1.25 margin. These data did not establish group equivalence under that margin. The exact sign-flip reference value was 0.0625. The margin result changed when a linear trend was removed. The time course, native late-window traces, source hashes, figures, and offline input arrays are retained. GPL analysis and extraction scripts are omitted, so the analysis implementation is not included. This reused clinical cohort does not test a live decoder or a neural cause.

SEEG · electrical stimulation · residual voltage variation · variance ratio · epilepsy · brain-computer interface