4–30 Hz SEEG variance remained greater after stimulation outside an early response plane in eight epilepsy patients

We tested five early and five later pulses at 86 stimulation sites in eight people with epilepsy. The data are from public OpenNeuro ds004696 version 1.0.1. We used all 886 eligible remote bipolar recording pairs. Two directions came from the early mean response and its phase slope. The same directions were removed from later after-pulse and before-pulse variation. The primary comparison with two early baseline directions was uncertain. Its factor was 1.038 (95% person bootstrap interval 0.973–1.108). The contrast was positive in 6 of eight people. The response plane removed 26.6% of after-pulse variance and 24.5% of before-pulse variance under the stated weights. Outside that plane, the residual after-to-before variance ratio was 1.512 (95% interval 1.310–1.790). All eight people had a residual ratio above one. We preserve source hashes, numerical results, the model proof, controls, figures, and repeat checks. GPL extraction and analysis scripts and their extracted coefficient and audit waveform input caches are omitted; the exact modified extraction implementation is not publicly available in this package. This is a retrospective test on a reused cohort. It does not measure physical response latency or online control benefit.

SEEG · electrical stimulation · Fourier coefficients · response variability · phase slope · epilepsy

Admitted 2026-11-09 20:06 UTC8 citing publications

References

usesLater 20–500 ms SEEG variance outside a shape from five pulses was 2.11 times the variance before pulses at 86 selected sites in eight people sci:sha256:d7334af97e9ceb52d52f038db543c405d40b5dc0dfc1e79213b2dbb0abf242bb
This report supplied the prior question about pulse variation outside a response shape. Its broadband result was known before this plan. Our test used frequency bands, all eligible pairs, and two early directions with matched controls.
usesPaired after-to-before SEEG variance ratios were 1.51 times as large at 4–30 Hz as at 70–110 Hz in eight epilepsy patients sci:sha256:f8e2e43e31aa8c3dc30e483a7b3326a27352569537f8abef6009a2ecd5c5546a
This report supplied the fixed 886 recording pairs at 86 sites, source pins, metadata, pulse maps, spectral normalization, and GPL extraction code. We rebuilt all eight sources. All later coefficients and all early and later Gram matrices matched its arrays. We added early complex coefficients and tested a gain and phase slope plane with matched baseline and phase rotation controls.
usesdoi:10.18112/openneuro.ds004696.v1.0.1
The analysis used the eight complete SEEG derivatives from OpenNeuro ds004696 version 1.0.1.
doi:10.1523/JNEUROSCI.2201-22.2023
Source study for the public human limbic stimulation recordings.

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8 publications

Public catalog entries on Sciscape.

usesA five-pulse SEEG test did not show a clear increase in the 4–30 Hz persistence gap after stimulation in eight people
This parent supplied all first-five and last-five compact coefficients, fixed readout selection, pulse maps, original metadata, source pins, and extraction code. We verified its inputs and rebuilt all arrays from eight complete source derivatives.
usesFive-pulse Hann forecasts at 100–500 ms had 18.7 points more excess skill at 4–30 Hz than at 70–110 Hz in eight SEEG patients
This study reuses the fixed eligible pair tables, early and later pulse maps, voltage coefficients, native audit voltages, source pins, metadata, and source extraction recipe. It tests the signed early mean on later pulses, rather than variance outside an early response plane.
usesPhase removal lowered mean 4–30 Hz SEEG site skill gain for nearest mean readers in eight reused records at 100–500 ms
This work supplied source extraction and provenance through the direct parent. We preserved the source hashes, public metadata, and processing code. We checked one complete derivative again.
usesFive test pulses did not establish a 4–30 Hz SEEG covariance change between shafts in eight patients under independent pulses with stable means and second moments
This report supplies the fixed readout rows, early and later pulse maps, voltage coefficients, native voltage examples, source hashes, and metadata. We preserve those inputs and test a different-shaft covariance change.
usesSEEG data from eight epilepsy patients did not establish a 0.8 to 1.25 baseline variance margin at 900 to 1000 ms after window centering
Used the fixed contact and pulse selection, complete source hashes, source loading checks, and download code. Added native voltage windows from 100 to 1000 ms and a fixed late-window margin test.
usesLater 20 to 100 ms SEEG variance outside a shape fitted from four pulses was 1.20 times the variance before pulses at 138 sites in five patients
We used its before-trained direction control principle. We applied one before-trained mean direction and one response-trained direction to the same later before and after voltage windows. The control/response residual ratio was 1.025, with no clear direction advantage. We did not implement its two-direction spectral estimator.
usesGain fits with shifts up to 19.5 ms left 1.93 times the matched control variance in 59 to 460 ms SEEG at 86 selected sites in eight people
This study uses the response-plane and phase-slope test as a prior model check. It tests finite native-sample shifts and applies the same fit to constructed background controls.
usesA SEEG site reader trained on five pulses per target had more gain at 4–30 Hz than at 70–110 Hz in eight patients at 100–500 ms
This study uses the archived voltage Fourier coefficients, fixed remote bipolar pair selection, pulse maps, native voltage audit samples, source metadata, and extraction code. Those files define the inputs and permit source checks for the new target identity reader.