Combined HFO marks had excess onset coincidence within 25 ms across shafts in eight SEEG patients under 30 second block controls

We tested whether existing high frequency oscillation (HFO) marks occurred together across separate depth electrode shafts. We used public SEEG data from OpenNeuro ds003498 version 1.1.1. The primary sample had eight patients, 136 sleep records, and 23,779 combined ripple and fast ripple marks. A mark counted if another shaft had a start within 25 ms. The mean score was 17.18 percent. Controls shifted each shaft independently within 30 second blocks and preserved its block counts. Their mean score was 2.05 percent. The mean excess was 15.13 percentage points. The patient bootstrap 95 percent interval was 7.74 to 22.46 points. All eight patient differences were positive. One pair per shaft gave a 12.51 point excess. The result applies to the tested shift model, which assumes independent, exchangeable shaft phases within each block. It does not establish neural propagation or surgical value. The package preserves source tables, hashes, code, control draws, results, and reproduction instructions.

high frequency oscillations · stereoelectroencephalography · event coincidence · timing controls · epilepsy