Interictal SEEG coherence marks SOZ-to-SOZ links but does not improve power models in 36 HUP patients

In 36 patients with HUP stereo-electroencephalography (SEEG), 3,687 bipolar pairs (392 SOZ pairs) were assessed using 20–90 s interictal clips from OpenNeuro ds004100 version 1.1.3. Broadband coherence and imaginary coherence between pairs on different shafts discriminated SOZ from non-SOZ pairs (mean AUC 0.601 and 0.616; Holm-adjusted p=0.011 and 0.005). The associations remained after within-patient regression on local power and line length (AUC 0.596 and 0.593; adjusted p=0.015), but did not occur within SOZ-containing shafts. Removing links to other SOZ pairs eliminated the discrimination (AUC 0.482), indicating that the finding reflects coherence among SOZ pairs across shafts rather than general network hub status. Adding coherence did not significantly improve a leave-one-patient-out power model (AUC 0.732 to 0.751; difference +0.019, 95% CI [-0.009, 0.047], p=0.21). Clips were short, behavioral state and anatomy were uncontrolled, and SOZ labels had coarse clinical resolution; this measure is not a blind single-channel marker.

stereo-electroencephalography · SEEG · seizure onset zone · interictal coherence · imaginary coherence · epilepsy