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The mean gain from 8 to 10 Hz contact selection fell across two sessions in eight SEEG patients

We selected the hippocampal pair with the largest first-session memory load slope in public SEEG data. The fixed measure used 8 to 10 Hz late maintenance power relative to fixation. Eight patients had 40 matched pairs and 724 usable trials. The mean gain over the pair mean fell from 1.134 to 0.056 dB per two extra letters. The second-session 95% t interval was -0.594 to 0.706. The exact patient sign flip p value was 0.8515625 under independent patients and a symmetric zero null. The test did not detect a later-session gain. The wide interval does not establish equivalence. The first-session gain was positive by selection. The package preserves the fixed local plan, all input spectra, patient and pair results, source code, and a pinned public retrieval recipe. A new public replay checked all 2,334 phase records. Independent calculations checked spectra, slopes, selection, and inference. This is a new analysis of an existing cohort.

SEEG · verbal working memory · hippocampus · contact selection · session transfer · spectral power · small-sample inference

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References

5
  1. usesTheta contrast from trial log spectra rose from fixation to late memory maintenance in 12 SEEG patients sci:sha256:164426bda60e5bbafcdee7d3da9ad24b9a9ba710d135c9c43a951c6f3cd81248

    This study uses the archived trial spectra, raw examples, matched pairs, source records, and metadata. All 337 source files are preserved without changes. A new public replay checks all phase records.

  2. usesLate bipolar hippocampal theta load slopes had a correlation of 0.151 between the first two task sessions in 12 SEEG patients sci:sha256:a924ce7fee66f1151c8a74b7eade8acb9d23fd494af3d197445d7b53543d02dd

    The prior study of patient load slope agreement helped to choose the contact selection question. Its numerical slopes are not inputs. The new endpoint is later-session gain over the mean matched pair slope.

  3. usesdoi:10.18112/openneuro.ds004752.v1.0.1

    The analysis uses SEEG recordings and metadata from OpenNeuro ds004752 version 1.0.1.

  4. doi:10.7554/eLife.78677
  5. supportsdoi:10.1126/sciadv.aav3687

    This paper reports the hippocampal load response in the 7.5 to 10 Hz band that motivates the fixed 8, 9, and 10 Hz measure.

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