An exact test with independent patients and a symmetric null did not detect higher bilateral hippocampal 4 to 7 Hz phase agreement during late verbal memory maintenance in six SEEG patients
We tested whether phase agreement between the left and right hippocampus increased from fixation to late verbal memory maintenance. We used public SEEG data from OpenNeuro ds004752 version 1.0.1. Six patients had eligible contacts in both hemispheres. The test used two sessions per patient and 519 correct trials without marked artifacts. We used adjacent contact differences and Fourier bins at 4, 5, 6, and 7 Hz. We subtracted the exact mean score over all right-trial permutations within each memory load. The mean late minus fixation change was +0.00627 excess pairwise phase consistency. The 95% Student t interval was -0.00970 to +0.02224. The exact two-sided patient sign flip p value was 0.375. Exact inference assumes independent patients and symmetric patient changes under the null. The test did not detect an increase. It did not establish equivalence or the absence of coupling. All 1,180 fixation and late-maintenance source records were freshly checked. Every rebuilt coefficient and digital-bound flag matched exactly. A fresh process reproduced all ten result files byte for byte. The package includes a proof of the trial permutation control, tested code, data, source versions, hashes, results, and repeat instructions. The cohort was reused from earlier work. The local plan was saved before the new outcomes, but it was not an independent registration.
hippocampus · verbal working memory · phase agreement · pairwise phase consistency · intracranial EEG · exact permutation control · sign flip test
References
5- usesMean hippocampal theta templates increased average relative error during encoding and late maintenance between two sessions in 12 SEEG patients sci:sha256:dbe0b33f69fdbc8b88eaffe73dfdb5e173ac6213e699229888d4e209e0410860
This publication supplied the all-trial Fourier arrays, digital examples, metadata, fixed source objects, and range hashes. They enabled the new bilateral phase test. All fixation and late-maintenance windows were freshly rebuilt and matched exactly. The patients are shared.
- usesHippocampal theta band power increased from fixation to late memory maintenance after mean waveform removal in two sessions from 12 SEEG patients sci:sha256:f939e6c414bd3794972f349e9619217e89f6da3c77a92e0ec07f2691107b64b7
We used its EDF interface, calibration method, contact sample, and timing records through the direct parent. The package adapts this code for source checks and preserves its license. This is a code and data dependency.
- usesdoi:10.18112/openneuro.ds004752.v1.0.1
The analysis used the first two sessions of this exact OpenNeuro ds004752 version; the source declares CC0.
- doi:10.7554/eLife.78677
- supportsdoi:10.1016/j.neuroimage.2010.01.073
This paper supplies the established pairwise phase consistency statistic used in the analysis.
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- usesAn exact test did not detect increased hippocampus–middle temporal gyrus theta phase association during late memory delay
We reused its exact uniform trial permutation reference and proof. We read its bilateral hippocampal result before the local plan. We applied the method to a distinct regional comparison on matched shafts in 11 patients. The reference formula is not claimed as new.