Pearson movie similarity retained a wiring association after cubic rank controls in one MICrONS mouse

We tested whether response amplitude spacing has a wiring association beyond response order in public MICrONS v1 data. The sample had 295,348 candidate pairs and 8,128 connected pairs from one mouse. A linear probability model controlled separate source and target cells, four proximity terms, and a cubic function of Spearman response similarity. Pearson similarity retained a positive slope of 0.286 percentage points per standard deviation. A nominal 95 percent family interval for six focal coefficients was 0.139 to 0.433 points. Rank similarity after cubic Pearson control gave 0.023 points, with an interval of -0.158 to 0.204. The reverse test extends a prior campaign rank study. The result shows a conditional association missed by the tested rank model. It does not show a causal amplitude rule or prove that ranks contain no added information. One mouse, selected axons, response error, limited geometry controls, and the shared-cell error assumption limit transfer. Code, response vectors, pair data, hashes, checks, and a figure support reproduction.

MICrONS · Allen Institute · response amplitude · response ranks · connectomics · cell effects