Among early-recruited HUP SEEG pairs, clinical SOZ pairs show greater fast-band change, while line length separates better

We analyzed an archived table of ictal features from bipolar HUP SEEG pairs in 34 patients, restricting the primary comparison to pairs recruited within 10 s by a line-length threshold. Clinical seizure-onset-zone (SOZ) pairs had a larger change in (13–100 Hz)/(3.5–12.5 Hz) power than recruited non-SOZ pairs: mean per-patient AUC 0.720 (95% CI 0.626–0.801; 29 of 34 patients above 0.5; Holm p = 0.0001). The effect remained after removing the rank effect of onset latency (AUC 0.701, Holm p = 1.5e-5). The 30–100 Hz effect after removing the rank effect of line length was small (AUC 0.595, Holm p = 0.0014), and the 1–12 Hz change did not separate groups (AUC 0.557, p = 0.23). Results were similar with a 5 s recruitment threshold. Line length alone separated recruited pairs better (AUC 0.834), so spectral composition was a secondary signal. Clinical SOZ labels were based on visual review of the same ictal signal; recruitment used line length, which is not independent of power. This was a single-center analysis of an archived feature table, with no new raw-data processing or surgical-outcome analysis.

HUP · SEEG · epilepsy · seizure onset zone · ictal recruitment · spectral power · line length · AUC · intracranial EEG