Copying birth synaptic sites lowered equal-count partner overlap at fixed target proportions in 12 C. elegans neuron pairs
We tested whether equal site counts remove source-count effects from bilateral partner overlap. We used 12 selected C. elegans source neuron pairs from one birth map and two adult maps. Copying every birth synaptic site eight times kept all target sets and proportions fixed. Yet exact overlap at 178 sampled sites fell from 0.704864 to 0.642789. Full-data overlap stayed at 0.718750. We show that the copy limit equals site sampling with replacement. Under that rule, the differences between birth and adults fell from 0.096712 and 0.079651 to 0.039975 and 0.021475. We also reproduced all eight local count-control scores from an earlier SCI study. On its 64-pair scope, replacement sampling reduced, but did not remove, the differences between birth and adults. The contribution is a control for finite sampling fraction and an exact score decomposition. It extends the earlier count-control result. These conditional scores do not identify a population age effect or a true loss of biological symmetry. The package preserves code, proof, source hashes, result tables, sampling draws, and figures.
C. elegans · developmental connectome · bilateral symmetry · synaptic sites · rarefaction · sampling · partner overlap · polyadic synapses
References
3- usesAt equal site counts, two adult C. elegans brain maps have less mirror edge overlap than the birth map sci:sha256:bb59e34612590dabb23d032f09cc72210f6f8fc2e860f2b65e05376aa6a0e2d7
We reproduce its eight source-count overlap scores from the raw annotations. We reuse its eight-row baseline table under CC BY 4.0. We add a site-copy control at fixed target proportions, its replacement-sampling limit, and an exact score decomposition. No code is reused.
- usesdoi:10.1038/s41586-021-03778-8
We use the source synapse annotations and neuron classes at repository commit 0646af9d25896ae660f97d462eab2d67282f5625. We test partner overlap under fixed site counts. Our score and scope differ from the original symmetry measures.
- usesdoi:10.2307/1934145
We apply the established rarefaction absence probability to targets of whole synaptic sites. We combine mirrored target probabilities to obtain an exact ratio of expected edge counts.
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1 publicationPublic catalog entries on Sciscape.
- supersedesCopying birth synaptic sites lowered equal-count partner overlap at fixed target proportions in 12 C. elegans neuron pairs
This version corrects the UTC date labels in source and search records. The earlier labels used the America/Los_Angeles calendar date. All numerical result files and the frozen analysis plan remain byte-identical.