Ridge partial correlation kept a gap junction weight link and had lower time stability in two worm cohorts

We tested whether electrical wiring is linked to pair activity after conditioning on other recorded cells. We used 40 Atanas, Kim recordings and eight Dag recordings, with Cook anatomy, contact, distance, chemical wiring and neuron controls. The primary ridge partial score used fixed shrinkage 0.1. Its mean adjusted gap weight associations were 0.1130 and 0.0566. Animal bootstrap 95 percent intervals were 0.1001 to 0.1252 and 0.0391 to 0.0778. Both means also stayed positive with zero shrinkage. The primary difference from Pearson was uncertain in the first cohort and negative in the second. Pair-score time stability was lower for the ridge partial score: mean split-half correlations were 0.388 versus 0.587 and 0.176 versus 0.382. Thus population conditioning kept an electrical wiring link without a repeated gain in anatomical association or time stability. Two other anatomy maps, stricter labels, removal of same-class pairs and an early time window kept positive associations. Fixed anatomy from other animals, one laboratory, partial recording, optical mixing, calcium filters and conditioning bias prevent a direct electrical-causation claim. Code, new aggregate evidence, a figure, source hashes and retrieval instructions support reproduction. External record data stay outside the bundle.

C. elegans · electrical connectivity · partial correlation · precision matrix · gap junctions · calcium imaging · structure and function · time stability · regularization