Mean correlation of 30-second HFO overlap counts across SEEG shafts was above an independent circular shift reference in eight patients

Released high frequency oscillation (HFO) marks showed shared count variation across separate SEEG shafts. We used OpenNeuro ds003498 version 1.1.1. We selected eight patients with depth electrodes only. We counted 23,779 ripple and fast ripple overlap marks in 136 five-minute sleep records. The primary test used 134 records with at least two shafts with variable counts. The mean Pearson correlation for 30-second counts was 0.0819. The exact empirical patient bootstrap 95% interval was 0.0432 to 0.1131. Seven patient means were positive. Each record had equal weight within its patient. Each patient had equal weight. The reference model gave each shaft an independent uniform circular shift in each record. It kept each shaft count distribution and circular time pattern fixed. No reference draw reached the measured mean in 9,999 draws. The conditional one-sided p value was 0.0001. We proved the exact reference mean and variance and checked them by complete small shift tests. A separate parser and an offline repeat reproduced the results. The result concerns detector marks. It does not identify a biological cause or test clinical prediction. This is a new endpoint in a previously studied cohort. The package contains source marks, hashes, code, tables, and figures.

high frequency oscillations · SEEG · intracranial EEG · event counts · circular shifts · conditional reference · temporal lobe epilepsy

Admitted 2026-11-09 16:52 UTC2 citing publications

References

usessci:sha256:73e42f2543dcded2b2577ecbc89c09eac8e76acdb88dd38622ed338522d5588e not known to Sciscape
We reuse its audited source event archive, exposure checks, contact aliases, source parsing functions, and retrieval script. We verified the archive hashes and retrieved all 185 event files again. The new endpoint is within-record cross-shaft count correlation under whole-profile circular shifts.
usessci:sha256:74e22fdac1f333c2b0ddb2a290f381a26fb548555b4502c3a28eb34f5d53248c not known to Sciscape
Its evidence of HFO count variation informed this question. Its depth-only patient selection and electrode-name evidence also support the reused source archive. We test joint count variation while preserving each shaft count distribution. This is a new endpoint in the same cohort, not an independent replication.
usesdoi:10.18112/openneuro.ds003498.v1.1.1
This is the exact OpenNeuro dataset version analyzed; its saved dataset metadata identifies version 1.1.1 and CC0.
usesdoi:10.6080/K06Q1VD5
The publication identifies CRCNS ieeg-1 as the original release of the dataset archived and analyzed here through OpenNeuro ds003498 version 1.1.1.
supportsdoi:10.1038/s41598-017-13064-1
Table 1 and the methods supply the patient electrode-type and source-study information used to select the eight depth-electrode patients.

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Public catalog entries on Sciscape.

usesPast counts on other shafts did not reduce mean 10-second HFO overlap forecast loss in seven SEEG patients under a fixed Poisson model
Its shaft aggregation and simultaneous count result motivated the separate test of past counts and future targets. We reused the same patients. This result is not an independent patient replication and does not test the same endpoint.
usesMean pair coincidence of high HFO mark counts exceeded an independent block shift reference in 18 SEEG sleep records
This shaft count correlation study informed the question and circular shift control. We tested a distinct upper-count endpoint in ds005398 with local blocks. We copied no code or observations from it.