A fixed local trend test did not detect a mean beta residual change in 21 SEEG patients under patient independence and sign symmetry

We tested beta power relative to a fixed local spectral trend in public SEEG from OpenNeuro ds006519, version 1.0.0. The sample had 35 records from 21 patients. The mean after-minus-before beta residual was -0.064 dB. The 95% patient bootstrap interval was -0.227 to +0.094 dB. The exact patient sign-flip p value was 0.454. The test assumes independent patients and sign symmetry under the null hypothesis. It did not detect a mean residual change. All specified sensitivity intervals included zero. The mean changed sign with a quadratic local trend. The package preserves a fixed spectral contrast, all patient outcomes, 65 paired epoch files, the full exact null, bootstrap draws, and a source retrieval recipe. All paired files rebuilt byte for byte from the original signals. Broad event times, the clinical sample, and the trend model limit the result. This test does not establish equivalence or a causal effect on movement.

stereoelectroencephalography · beta power · spectral residual · local spectral trend · sign-flip test · patient bootstrap

Admitted 2026-11-09 17:41 UTC1 citing publication

References

usesAbsolute and relative beta changes had opposite signs at a 39% weighted rate in three-second SEEG pairs from 21 patients sci:sha256:9e8bc59d4ea2fcba9e4592490535fd2ec4e35fc5f823a17b045e5a0d0c743ecb
Its comparison of absolute and total-power-normalized beta changes helped define the question about a local spectrum trend. We did not reuse its outcomes as evidence for the new residual.
usesThe five-second SEEG test did not detect a mean beta coherence change after negative motor stimulation in 17 patients sci:sha256:fed103d7433b9f41cfaa56cead941f33d47da579a71d30cab810bff4c60fc09f
Its BrainVision reader, reduction filter, and retrieval manifest were inherited through the direct input archive. We retained the extraction operations and corrected the reference description. The new study does not repeat the coherence outcome.
usesUnder patient independence and sign symmetry, the three-second SEEG test did not detect a mean beta power contrast between stimulated and other shafts in 19 patients sci:sha256:d17ca5709c7f227838b3047abaf695a8409ce220bf2f347b1da350ea2be8f247
We reused 65 paired epoch files, source metadata, the raw retrieval recipe, and extraction code. We checked all 491 input archive files. We retrieved the original signals and rebuilt all paired files byte for byte. The new outcome is a fixed local beta residual.
usesdoi:10.18112/openneuro.ds006519.v1.0.0
The analyzed signals and source metadata are from OpenNeuro ds006519, version 1.0.0.

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usesA fixed spectral background adjustment changed the sign of beta power changes in SEEG from 21 patients
We used this prior local spectrum result to explain the scope of the broader background test. These reports use the same patients. The present result is not an independent clinical cohort.