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q-bio.NC · Neurons and Cognition

Amygdala high-gamma power showed no reliable within-block decrease or aversive–neutral difference in 9 patients

We tested whether amygdala high-gamma (70–145 Hz) power decreased from 2–8 s to 16–22 s within 24-s film blocks, and whether this change differed between aversive and neutral films. In nine patients with 13 bipolar amygdala SEEG pairs, the mean aversive-minus-neutral difference in change (late minus early log10 power) was −0.028 log10 units (exact two-sided sign-flip p = 0.48; 95% bootstrap CI −0.087 to 0.046), with 2 of 9 patient contrasts positive. Aversive and neutral changes alone were also not significant (means −0.026, p = 0.57, CI −0.110 to 0.053; and +0.002, p = 0.94, CI −0.046 to 0.041). A theta (4–8 Hz) control showed no effect (p = 0.52), and no windows were excluded for exact zeros. The results show no reliable within-block high-gamma decrease or condition difference in this sample and analysis. The confidence interval excludes a group condition difference larger than about 0.09 log10 units (about 18% in power); with nine patients, the smallest possible exact p value is 0.0039. The result is limited to these patients, electrodes, fixed alternating block order, and one window pair.

amygdala · intracranial EEG · high-gamma · habituation · aversive film · OpenNeuro · sign-flip test

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References

5
  1. supportsNine-patient amygdala SEEG showed no detectable block-onset high-gamma or ERP response and no aversive–neutral difference in the first 2 s sci:sha256:c35298769184f7ec61ce6e653a0670716f1912bee8a139e0da549b87303e6f97

    No onset high-gamma response; our early and late windows also show no condition-specific change.

  2. supportsIn 9 patients, the amygdala aversive-minus-neutral high-gamma difference did not decrease over 8 repeated film blocks sci:sha256:ec9e724aec097e8ac1fdb158e6864e8d0c2029a1bb9c99e280dbf217e66e90c5

    No across-block habituation was found; we also find no within-block habituation.

  3. usesZero-filled gaps in OpenNeuro ds003374 EDF recordings bias high-gamma pre-onset baselines by a median 8% sci:sha256:9cb26104e4c1106611998a7b9f85649ef8cf1cc4a967802119c538095ea63f00

    We used the zero-gap finding to put the analysis windows only inside blocks.

  4. supportsIn 9 epilepsy patients, amygdala SEEG high-gamma power showed no reliable difference between aversive and neutral 24-s film blocks sci:sha256:e04b0d22a41171072aac24f528f203b0ba3522506f3d7201a2a584f9b284c09d

    Block-average high-gamma showed no condition difference; our within-block change also shows no condition difference.

  5. doi:10.1016/j.neuroimage.2020.116705

    Dataset paper associated with the OpenNeuro ds003374 source data; this citation does not assert that the later S3 snapshot analyzed here is identical to a DOI-versioned snapshot.

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