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q-bio.NC · Neurons and Cognition

Novel images raised visual cortex responses of RS, FS and Vip units but not of Sst units, which fell at 20-70 ms, in 71 mice of Allen Visual Behavior Neuropixels

Slice and EM wiring show a disinhibitory chain in cortex: Vip cells inhibit Sst cells, which inhibit pyramidal cells. We tested whether image novelty changes spiking of cell classes in the sign pattern that this wiring predicts. We used Allen Visual Behavior Neuropixels (153 sessions, 81 mice). In each unit we compared responses to 6 non-shared images with responses to 2 shared images, in Novel minus Familiar sessions. Optotagging identified Sst units (31 mice) and Vip units (18 mice). In visual cortex of 71 G-trained mice (active block, 20-250 ms, log rate ratio, 95% mouse-bootstrap interval), novelty increased regular-spiking units by +0.27 [0.25, 0.30], fast-spiking units by +0.48 [0.43, 0.52] and Vip units by +0.59 [0.35, 0.89]. Sst units did not increase (+0.03 [-0.05, 0.09]); at 20-70 ms they decreased (-0.21 [-0.29, -0.13]). At 70-150 ms, regular-spiking rate rose 49% while Sst rate did not change. LGd showed no effect and LP a small one, so the effect appears between thalamus and V1; inside cortex it did not grow along the anatomical hierarchy (V1 largest for regular-spiking units). The passive replay block gave the same pattern. The pattern fits Vip-to-Sst disinhibition and does not fit a pure feedforward drive increase. But the early Sst decrease began at about 35 ms, before a detectable Vip increase, so the timing does not show that Vip causes it. Limitations: for Sst and Vip units novelty is confounded with image set (only G-trained Cre mice; for RS/FS the image-set term was 0.02-0.07), Vip units are few (81), and the wiring argument uses connection signs, not a fitted circuit model. Code, the unit table, statistics and figures are included.

Visual Behavior Neuropixels · Allen Institute · image novelty · familiarity · optotagging · Sst interneurons · Vip interneurons · disinhibition · fast-spiking · visual cortex · anatomical hierarchy · structure-function · mouse

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References

12
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    Allen Visual Behavior Neuropixels session NWB files and metadata (public S3 bucket) are the data of this study.

  2. supportsdoi:10.1016/j.celrep.2024.114521

    Nitzan et al. 2024 reported stronger novel-image responses in visual cortex and weaker ones in thalamus in the same data; we confirm this with a within-unit contrast and extend it to optotagged classes.

  3. doi:10.7554/eLife.50340

    Two-photon Vip novelty responses in the Allen Visual Behavior project.

  4. doi:10.1101/2023.02.14.528085

    Two-photon novelty effects across Vip, Sst and excitatory cells.

  5. usesdoi:10.1038/s41586-019-1716-z

    Anatomical hierarchy scores.

  6. usesdoi:10.1038/s41586-020-03171-x

    Hierarchy score values for the recorded areas and Neuropixels methods.

  7. doi:10.1126/science.abj5861

    Slice connectivity among cortical cell classes, source of the wiring prediction.

  8. doi:10.1038/nn.3446

    Vip-to-Sst inhibition (inhibition of inhibition).

  9. doi:10.1038/nature12676

    Vip disinhibitory control.

  10. In 61 Allen Visual Behavior Neuropixels sessions, task engagement decreased the axonal-wiring slope of fast inter-regional co-variation by 24%, as part of a proportional decrease of coupling sci:sha256:63daa56425a27eea758808a18f0552cc53e773421e3686dbcee77b3dcd1346cd

    Prior campaign study of the same VBN data (engagement and wiring slope).

  11. sci:sha256:c1bceb6a7829833d7fc212cb3ccdb384246b26084895536189b17e809d2e7c55 not known to Sciscape

    Optotagged Sst units in awake visual cortex receive facilitating spike transmission; relevant to the late Sst increase.

  12. sci:sha256:815b4700cfeb985e4043844784781f6387b67c9b10140be6f8163b5da39ba407 not known to Sciscape

    In vivo spike couplings compared with slice wiring by cell class.

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