With linear age and Gender adjustment, 65 processed ds004504 v1.0.9 EEG records had a larger Alzheimer-control theta-to-alpha contrast in an early alpha pattern than in its remainder.
We tested whether the Alzheimer-control EEG theta-to-alpha contrast depends on a fitted spatial pattern. We used OpenNeuro ds004504 version 1.0.9. We fitted each person's leading alpha pattern on the first ten accepted 10-second windows. We measured its power and the remaining power on the last ten windows. The sets did not share windows. The main sample had 36 Alzheimer records and 29 control records. With linear Age and recorded Gender adjustment, the contrast was 0.689 log10 units in the pattern and 0.441 in the remainder. The paired difference was 0.248, with a 95% stratified person-bootstrap interval of 0.120 to 0.366. Time reversal and all other fixed checks gave positive differences. A descriptive follow-up found a smaller alpha power fraction in the pattern in the Alzheimer group. This is an association in one processed scalp EEG cohort. It does not locate a neural source or establish diagnostic accuracy. The package preserves all matrices, source metadata and hashes, code, fitted weights, bootstrap draws, figures, and reproduction instructions. Three source records passed new signal checks. A second full analysis reproduced every result table and numeric array.
scalp EEG · theta-to-alpha ratio · alpha spatial pattern · Alzheimer disease · power partition · person bootstrap
References
5- usesCommon average reference changes posterior theta-to-alpha ranks in 88 ds004504 v1.0.9 records with source processing fixed sci:sha256:2047e7d0ae35196950f5421eb9237a3b0a817c451fabcbdedd0b92ad776f3431
The study uses its unchanged 88-person real band power matrix archive, window table, source manifest, spectral code, and retrieval code. New separate-window alpha patterns and group contrasts are calculated from those matrices.
- usesThe adjusted Alzheimer and control alpha entropy pooling contrast had a 95% interval that included zero in 65 ds004504 v1.0.9 records with 100 accepted seconds sci:sha256:10db42615f29e61efaf2b3de206acccb016147e93d677df99393bfccbe770256
Its alpha matrix entropy study gave context for the spatial power question and for the effect of pooling windows.
- usesWith source processing fixed, linear age and gender adjustment gave a larger Alzheimer-control theta-to-alpha contrast for the posterior mean than for deviations in ds004504 v1.0.9. sci:sha256:12e08d9b54221b4422c626e1eef8c305cba3997da5a90b96bccfefa1ed927da4
Its fixed posterior mean and deviation comparison motivated the question about fitted alpha patterns and their remainder.
- usesdoi:10.18112/openneuro.ds004504.v1.0.9
Source data: processed eyes-closed EEG from the exact OpenNeuro ds004504 version 1.0.9 snapshot used in this study.
- supportsdoi:10.3390/data8060095
Dataset descriptor cited for the source processing steps described in the publication.
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