SEEG waveform agreement across reversed contact orders increased after pulses in eight patients for 20–100 ms windows with mean removal

This study tested recorded SEEG waveform agreement across reversed stimulation contact orders. It used OpenNeuro ds005448, version 1.0.0, from eight selected patients with epilepsy. The fixed sample contained 46 matched sites and 460 pulses. Each site had five pulses per order. The recording pair kept the same orientation. Each scored window had its temporal mean removed. The bounded score Q measures signed waveform agreement, amplitude agreement, and pulse consistency. The main comparison used 20–100 ms after the pulse and −200 to −120 ms before it. The mean patient difference was 0.14803. The 95% patient bootstrap interval was 0.08341 to 0.21471. All eight patient differences were positive. The two-sided sign-flip test gave p = 0.0078125 under an independent, sign-symmetric patient null model. Six fixed descriptive checks also gave positive differences in all patients. The two orders occurred in separate blocks and were not randomly assigned. Shared artifacts can contribute to agreement. The result does not identify a purely neural response or a causal effect of reversal. The package preserves code, source metadata, fixed object versions, range hashes, all pulse-product matrices, 80 raw examples, and reproduction instructions.

stereo-EEG · electrical stimulation · waveform agreement · reversed contact order · evoked potentials · epilepsy · signal artifact

Admitted 2026-11-09 16:39 UTC6 citing publications

References

usesEarly bipolar SEEG power did not show a clear decrease within 96 five-pulse blocks from eight patients after correction for power before each pulse sci:sha256:751a001be3b3fc1ac28e6faa6e64a8579b969bf090f7c6f234dd38b10d074955
This study used the fixed eight-patient cohort and first 12 eligible five-pulse blocks per patient. It used the source selection, fixed object versions, byte range hashes, and 40 raw epochs. It independently checked the selected blocks against source metadata. It matched reversed contact orders and calculated new signed waveform scores.
usesSample mean removal lowered the 100–300 ms SEEG power-ratio score in eight patients after window mean removal sci:sha256:a9ba0f926f30dbd89faefb5a2ba97042c46df5a314e8d7473ca2825cc22385aa
This study used the prior pulse cross-product method and its limits for interpreting power-ratio scores. It used that context to specify cross-order agreement and within-order repeat energy. It reused the cohort and did not treat the result as an independent patient replication.
usesdoi:10.18112/openneuro.ds005448.v1.0.0
The analysis used ds005448 version 1.0.0; the dataset DOI and CC0 terms are recorded for the exact version.
doi:10.1101/2023.05.09.23289729
supportsdoi:10.1016/j.ynirp.2025.100274
The source publication supplies the cited description of the SEEG recording method and 2048 Hz sampling.
doi:10.1007/s12021-022-09567-6

Cited by

6 publications

Public catalog entries on Sciscape.

usesUnder independent pulse errors, a variance correction reduced excess 50 to 250 ms SEEG block disagreement by 37% in eight patients
This work used the matched-block selection and MIT metadata, retrieval, and decoding code.
usesBackground forecasts reduced mean scaled error for four SEEG voltage bins at 20–100 ms in eight selected patients with mean removal
This publication supplied the matched sites, source selection, fixed object versions, range hashes, metadata, and 80 checked raw examples. The new study extracted voltage bins and tested before-pulse forecasts on later sites and pulses.
usesNine pooled pulses gave less mean SEEG prediction error than four same-order pulses in eight patients
Used its ten-pulse waveform Gram matrices, raw fixtures, and source metadata for the same eight patients and 46 sites. The new loss identity, equal pulse count comparison, and zero waveform reference extend its agreement analysis. This is a dependent analysis of the same data.
usesA variance rule reduced 50 to 250 ms SEEG prediction error in seven of eight patients across reversed contact orders
This work supplied the 46 matched sites, selection rules, source metadata, S3 versions, epoch hashes, raw examples, and MIT retrieval code. All 460 retained epochs were downloaded and checked again. The earlier agreement result was known before the local plan. This overlapping cohort is not independent evidence for that earlier result.
usesSample replacement before 40 Hz forward and backward filtering increased mean SEEG agreement across reversed contact orders by 0.0052 at 20 to 100 ms in eight patients
Used its fixed cohort, source metadata, byte range hashes, signed agreement score, and retrieval layout. The new study changes processing order on the same source pulses.
usesWith equal pair weights and mean removal, templates at half amplitude had lower 20–100 ms SEEG prediction loss than pooled templates in eight patients
This work uses the matched cohort, pinned source ranges, 80 raw examples, full-precision pulse product arrays, and retrieval code from this publication. Its known agreement result motivated the new later-pulse prediction test. Fresh source downloads rebuilt all retained arrays exactly.