Mean FRandR count variance in 30-second windows exceeded a model with random five-second bin order in sleep SEEG from nine patients

We tested supplied FRandR marks in 153 five-minute sleep SEEG records from nine patients. FRandR is a fast ripple that overlaps a ripple. We proved an exact mean for count variance under random order of five-second bins. The mean patient ratio of observed to model variance was 1.314. Eight ratios were above one. The median was 1.074. Two patients accounted for 88.17 percent of the mean excess. None of 9,999 random draws reached the observed mean. The conditional one-sided simulation p value was 0.0001. A ten-second bin check gave a mean ratio of 1.167 and p = 0.0002. A shared order check gave p = 0.0002. The primary model assumes uniform bin orders within each record and independent permitted orders between records and patients. These results show time structure in supplied event counts under that model. They do not identify a neural cause or show clinical value. The package preserves 655 source files, hashes, new code, proof, count arrays, random draws, figures, checks, and repeat instructions.

high-frequency oscillations · SEEG · count variance · conditional randomization · temporal order · sleep · epilepsy