Wake and N3 correlation ranks agreed in 12 fMRI participants and had uncertain agreement in 28 SEEG patients after distance and node controls

We tested whether the relative strength of distant cortical correlations persists from wake to N3 sleep in two separate human studies. The shared prediction was positive within-person agreement after distance and node effects were removed. We used 30-45 Hz power envelopes from the MNI SEEG atlas and regional BOLD signals from the Tagliazucchi/Lehue release. A local plan fixed the score and participant split before new edge results. Discovery used nine SEEG patients and four fMRI participants. Confirmation used 28 other SEEG patients and 12 other fMRI participants. The mean residual rank score was 0.0022 in SEEG (95% person interval -0.0414 to 0.0467; 15/28 positive; Holm p=0.4253). It was 0.3340 in fMRI (0.2745 to 0.3923; 12/12 positive; Holm p=0.00048828). The fixed shared criterion failed. Mean-signal, distance, anatomical-group and later-window checks retained this discordance. Short-window SEEG wake maps also had weak internal agreement, so the result cannot establish loss of an underlying neural pattern. The cohorts, signals, regions and time windows differ. Motion covariates are absent from the BOLD release. There is no causal claim or independent new-cohort replication. The package preserves code, plans, source hashes and terms, all person and edge results, phase controls, figures and repeat instructions. Source waveforms remain external.

human neuroscience · SEEG · fMRI · N3 sleep · functional connectivity · rank correlation · failed transfer · subject-level inference