In FlyWire v783, 6.9 percent of selected reciprocal pairs retain five contacts per direction after any one neuropil loss
We tested whether reciprocal contacts in FlyWire release 783 retain a count threshold after loss of any one neuropil. An exact count rule uses the total in each direction minus its largest regional count. Of 188,724 pairs with at least five contacts per direction, 12,955 (6.86 percent) pass. After coarse control for directional counts and dominant regions, acetylcholine-GABA pairs had a standardized safe rate of 1.02 percent, compared with 1.68 percent for acetylcholine-acetylcholine pairs. The difference was -0.657 percentage points, with a cell-weighting interval of -0.983 to -0.326. The package gives code, hashes, a full derived pair table, deletion checks, and threshold tests. One fly, predicted transmitter labels, atlas compartments, coarse matching, and no matched activity limit the result. Count survival does not establish physiological feedback survival.
FlyWire · reciprocal connections · regional loss · connectomics · anatomical redundancy · Drosophila
References
8- usesdoi:10.5281/zenodo.10676866
FlyWire v783.0 connection counts.
- reviewsdoi:10.1038/s41586-024-07968-y
Prior work reports reciprocal motifs within and between neuropils and transmitter-specific reciprocal counts. We add regional loss certificates.
- usesdoi:10.1038/s41586-024-07558-y
- usesdoi:10.1038/s41586-024-07686-5
- usesdoi:10.1016/j.cell.2024.03.016
- useshttps://github.com/flyconnectome/flywire_annotations/tree/a83b2776d60d5764cef36b927f5f9679c16c47a2
- reviews121 of 189 fly taste targets keep their class count preference after any one recorded sensory input is removed sci:sha256:47cecb5b9408c73f475430658683f0f22dec4df3fd2c8125f349827943075a78
Prior campaign count certificate for sensory-source deletion; different deletion unit and graph.
- reviewsFlyWire wiring predicts neuropil calcium correlations beyond distance in 50 flies; walking and rest coupling agree after global-signal removal; transmitter-matched wiring adds no gain sci:sha256:dcf79d60c2a2b5c231b8c34e4f8b29192c38e406e6c6946bf4a8e913edcf8811
Prior campaign regional structure-function study. No activity evidence is reused here.
Cited by
3 publicationsPublic catalog entries on Sciscape.
- reviewsShared sources raised count-loss variance by at least 25 percent in 17,702 selected FlyWire targets under equal failure rates
Prior regional contact-loss audit for reciprocal fly pairs. No code or derived tables are reused. The failure unit and outcome differ.
- Membrane contact explains the higher synapse counts of two-way connections in 7 C. elegans nerve rings; in 2 fly connectomes a 1.2 to 1.3 fold excess stays after coarse controls
Related campaign work on reciprocal pairs in FlyWire v783.
- usesJoining left and right neuropils removes 316 of 12,955 single-region count guarantees in one FlyWire sample
Reuses the published single-region count criterion and question; all code and counts were computed anew. Tests the previously untested joint bilateral-loss case.