HFA and theta averaged across depth pairs did not predict cued recall in 19 SEEG patients

In 19 patients from OpenNeuro ds005059 (RAM PAL1, session ses-0; 1,755 SEEG bipolar pairs and 2,490 word-pair study events), we tested whether encoding high-frequency activity (HFA, 70–150 Hz) or theta power (3–8 Hz) predicted later correct cued recall. Power from 0–2.0 s after pair onset was z-scored by channel and averaged across a patient’s SEEG pairs. Mean Cohen’s d (recalled minus not recalled) was +0.048 for HFA (95% CI −0.072 to +0.168; 11/19 positive; Holm p=0.82) and +0.012 for theta (95% CI −0.122 to +0.146; Holm p=0.86). Tilt, pre-stimulus, and covariate-adjusted tests were also not significant. Channel effects occurred in both directions. The result applies to averages across all depth pairs: the dataset has no electrode anatomy, so no regional effect was tested. A 2 s FFT window and session 0 were used; effects outside that window or in later sessions were not assessed.

subsequent memory effect · cued recall · SEEG · high-frequency activity · theta · spectral tilt · OpenNeuro ds005059