At 24 sites, one repeat mode lowered error in six SEEG patients and two fMRI panels; a zero residual pattern gave lower error

We tested removal of one repeat-variation mode from human sound responses. Separate public studies supplied SEEG high-gamma activity and two BOLD fMRI panels. Each person supplied 24 sites and three response repeats. Different sounds set the mode and measured its error. Class means and spatial means were removed. Development used two patients and four MRI adults. A local code lock preceded tests in six other patients, 16 B2021 adults and eight NH2015 adults. Mean error reductions were 8.91, 12.12 and 11.13 points of raw test response variance. Added reductions over a uniform random direction were 6.50, 9.83 and 8.69 points. All 30 people had both gains. The shared rule passed Holm correction over three claims, p=0.046875. The original claims of excess signal loss and harmful removal failed. Sound and person refits assess panel sensitivity. A later exploratory check found lower error from a zero residual pattern in every person. A pre-onset SEEG check also gave a removal benefit. Thus the fixed gain does not show useful sound decoding or a sound-specific neural process. Independent-source models can give signal loss and either error benefit or harm after common measurement mixing. Separate cohorts, source selection, three repeats, unequal filters and fixed sounds limit scope. Code, source pins and terms, all failures, figures and repeat steps are supplied. Original neural arrays remain external. No common neural cause or causal effect was established.

human neuroscience · SEEG · fMRI · auditory cortex · repeat variation · denoising · cross-validation · negative results