In 13 mice, initial neighboring spine pairs showed no clear excess shared fate under fixed segment turnover counts
We tested whether nearby dendritic spines survive or disappear together beyond each imaged segment's turnover count. We used released mouse visual cortex data from Tsimring and colleagues. The initial neighbor graph gave 855 pair records from 13 mice across two intervals. Pair records can repeat across intervals. Each mouse had equal weight. Shared fate occurred in 55.55% of weighted pair records. Uniform label permutations with fixed segment retention counts gave an exact expectation of 54.13%. The excess was 1.42 percentage points. Its 95% whole-mouse bootstrap range was -1.53 to +4.35 points. An independent-label reference instead gave an excess of -2.69 points. The exact finite count correction was 4.12 points. Initial stimulus-residual correlation had a positive covariance with shared fate. Its conditional tail score was 0.0295, or 0.0590 after adjustment for the two planned tests. Area, activity, graph degree, and mutual-neighbor checks kept substantial uncertainty. Thus, this sample did not establish excess shared fate or a general activity-dependent joint fate rule. The contribution adds a checked pair dataset and exact conditional controls. It does not prove independent turnover or identify a plasticity mechanism. The package preserves code, source provenance, compact inputs, draw scores, figures, numerical checks, and repeat instructions.
dendritic spines · structural plasticity · shared fate · nearest neighbors · calcium imaging · conditional randomization · finite population correction
References
5- usesdoi:10.6084/m9.figshare.28738592.v1
We use the pinned initial binocular spine records, trial amplitudes, structural labels, and neighbor summaries.
- usesdoi:10.1038/s41467-025-60825-y
The study supplies the biological data and source definitions. We test joint pair fate in a new analysis.
- usesIn 10 mice, equal mouse weights reduced the early binocular response correlation rise from 0.051 to 0.007 in 81 fixed spine pairs sci:sha256:c97d0624765e841d3140bb78b82cd769c0456156be9391a76acdff689c7019f1
We use its three-correlation rule to recover source neighbor identities. We rebuild the compact inputs from the original table.
- usesInitial neighbor activity gave an uncertain 0.4% gain in additive five-day spine retention models across 13 mice sci:sha256:e76d8bbc3bc918ce1b143bb764f45c6822a94633a810e3b0894cd75cdd13bdd8
We compare our new source extraction with its compact initial records. Its prediction target is individual retention, not joint pair fate.
- doi:10.7554/eLife.46966
Local activity clusters support the question of how nearby input groups persist.
Cited by
0 publicationsPublic catalog entries on Sciscape.
No incoming citations on Sciscape.