Shared input raised predicted response agreement in linear models with area weights for inhibitory maps from six mice
How do punctum area and shared input affect predictions of inhibitory map stability? We tested baseline hippocampal CA1 data from six mice in Klimmt et al. (2026). We matched 1,226 inhibitory punctum episodes across seven imaging days. The data describe 30 neurons and 62 neuron-compartment groups. From Day 1 to Day 13, retained initial area minus retained count was +0.002 in basal dendrites, -0.007 in the soma, and +0.027 in the axon initial segment. All 95% intervals included zero. Six corrected tests gave no clear area advantage in retention or map overlap. This agrees with the source size-survival result and does not establish equal retention. We then applied a linear rule with area weights and equal variance at all inputs. In the soma, predicted response correlation rose from 0.186 with independent inputs to 0.817 with input pair correlation 0.5. These are assumed input conditions, not measured activity. The package preserves the source workbook, compact data, audit, code, results and three figures. A fresh replay matched all 19 output files and the headline figure. The study does not measure inhibitory currents or behavior changes.
inhibitory synapses · structural plasticity · hippocampus · gephyrin · input covariance · structure and function · reproducible analysis
References
3- usesdoi:10.1038/s41467-026-77800-w
We use the baseline inhibitory punctum area, presence and count tables from the source workbook. We credit the original compartment survival result to this study.
- doi:10.1016/j.neuron.2016.01.010
This study reports recurrent inhibitory synapses at persistent sites. It motivates our merged-site sensitivity test.
- doi:10.1016/S0896-6273(00)80382-7
This study links GABA-A receptor number to inhibitory current size. It motivates an area-weight assumption but does not validate that assumption for our source puncta.
Cited by
4 publicationsPublic catalog entries on Sciscape.
- usesA fixed-count timing test found no clear excess grouping of initial inhibitory site losses in six mice
We reuse audited CSV tables and independently check every row against the source workbook. The new test concerns first-loss timing.
- usesAdding a prior turnover term raised linear test error for two-day growth of surviving inhibitory puncta by 0.35% in six mice
We use its checked data arrangement as an extraction reference. Our independent extraction matches every field. We test delayed growth rather than response correlation.
- usesWith turnover totals fixed and enough contacts for each loss, somatic inhibitory puncta had excess two-day gain and loss agreement in six mice
We use its audited source-table mapping and missing-image decision. We test gain and loss timing rather than map overlap or assumed response covariance.
- usesChanges at other inhibitory puncta gave no clear gain in two-day size estimates under two rules in six mice
We retain its source-audit decisions and extend its structural map analysis. New code independently extracts the workbook.