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None of six selected cortical time scale orders passed both SEEG and fMRI sign tests in test participants

We tested whether selected regional orders of temporal persistence had support in both human SEEG and fMRI from separate studies. We reused RAM memory task fits and MICA-MICs resting BOLD series. Strict cortical labels retained 1,862 electrical pairs in 122 people. A fixed person split gave 61 discovery and 61 test SEEG people, and 25 discovery and 25 test BOLD people. Only 10 of 561 named region pairs met coverage limits in both splits. Discovery selected three common and three opposite orders. Exact directional binomial tests used test people only. Holm correction covered all 12 tests. No region pair passed in both modalities. Three BOLD tests passed; no SEEG test passed. The selected electrical tests had only 14 to 26 people. At a conservative local level, power for a true directional probability of 0.7 was 4.7 to 22.9 percent. Several measured differences also depended on grid edges or estimator choice. The result does not establish absence of a shared neural order. The package provides the failed transfer test, code, source data and receipts, all predictions and controls, three figures, and exact repeat checks. The split is internal validation in reused cohorts, not an external replication.

human neuroscience · SEEG · fMRI · time scales · regional order · subject split · negative result · coverage · reproducibility

Admitted 2 citing publications

References

9
  1. usesParalimbic cortex had longer SEEG knee time scales but shorter BOLD time scales than heteromodal cortex in two human cohorts sci:sha256:b100a1ef070bf66d5ca5c4787e829f728518d346f554197af5da2177df99978b

    We reuse its verified source fits, contact labels, BOLD time series, source receipts and regional processing code. We add split participant regional prediction tests.

  2. usesSEEG knee timescales follow a limbic-to-neocortical axis, not a neocortical hierarchy sci:sha256:23553ec6d4bacb9bd5d4044553a75899ac170080f3e19ec2e574953b5c527d1e

    This cited source supplies the cortical electrical fit and label chain.

  3. usesMedial temporal SEEG pairs had longer aperiodic-knee timescales than lateral pairs in 206 RAM patients sci:sha256:5baa137385890b67e049fc04ffb0e904ebd31927f9bb21f7810e5e1f94328bf1

    This source specifies the knee fitting method.

  4. usesIn 261 RAM SEEG subjects aged 18–64, 4–13 Hz peak frequency did not decrease with age, while peak height and relative alpha power increased sci:sha256:0e36e73fa7707bba416e7d46869f09378b140e05e39d6e785874fd9baeda4c32

    This source supplies the original electrical spectrum derivation and raw block provenance.

  5. usesdoi:10.18112/openneuro.ds004789.v3.1.0
  6. usesdoi:10.18112/openneuro.ds004809.v2.2.0
  7. usesdoi:10.1038/s41597-022-01682-y

    We use its public MICA-MICs regional BOLD derivatives at the stated content snapshot.

  8. doi:10.7554/eLife.61277
  9. doi:10.1162/IMAG.a.1248

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